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6SMW

A. thaliana serine hydroxymethyltransferase isoform 2 (AtSHMT2) in complex with pemetrexed

Summary for 6SMW
Entry DOI10.2210/pdb6smw/pdb
DescriptorSerine hydroxymethyltransferase 2, mitochondrial, [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE, 1,2-ETHANEDIOL, ... (7 entities in total)
Functional Keywordsshmt, antifolate, transferase
Biological sourceArabidopsis thaliana (Mouse-ear cress)
Total number of polymer chains4
Total formula weight219181.90
Authors
Ruszkowski, M.,Sekula, B.,Dauter, Z. (deposition date: 2019-08-23, release date: 2020-01-08, Last modification date: 2024-01-24)
Primary citationRuszkowski, M.,Sekula, B.,Ruszkowska, A.,Contestabile, R.,Nogues, I.,Angelaccio, S.,Szczepaniak, A.,Dauter, Z.
Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models.
Sci Rep, 9:19614-19614, 2019
Cited by
PubMed: 31873125
DOI: 10.1038/s41598-019-56043-4
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.54 Å)
Structure validation

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