6SMW
A. thaliana serine hydroxymethyltransferase isoform 2 (AtSHMT2) in complex with pemetrexed
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Serine hydroxymethyltransferase 2, mitochondrial | polymer | 480 | 53545.0 | 4 | UniProt (Q94C74) Pfam (PF00464) | Arabidopsis thaliana (Mouse-ear cress) | AtSHMT2,Glycine hydroxymethyltransferase 2,Serine methylase 2 |
| 2 | E, P, Z (A, B, C) | [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE | non-polymer | 336.2 | 3 | Chemie (PLS) | |||
| 3 | AA, BA, CA, DA, EA... (C, A, D, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 38 | Chemie (EDO) | |||
| 4 | GA, N, SA (C, A, D) | 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID | non-polymer | 427.4 | 3 | Chemie (LYA) | |||
| 5 | LA (C) | SERINE | non-polymer | 105.1 | 1 | Chemie (SER) | |||
| 6 | XA (D) | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 1 | Chemie (PLP) | |||
| 7 | AB, BB, YA, ZA (C, D, A, B) | water | water | 18.0 | 1936 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 41 - 517 (UniProt: Q94C74)
| PDB | External Database | Details |
|---|---|---|
| Ser 38 | - | expression tag |
| Asn 39 | - | expression tag |
| Ala 40 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 214180.1 | |
| Non-Polymers* | Number of molecules | 46 |
| Total formula weight | 5001.8 | |
| All* | Total formula weight | 219181.9 |
