3FER

Crystal structure of n-terminal actin-binding domain from human filamin b (tandem ch-domains). northeast structural genomics consortium target hr5571a.

Summary for 3FER

DescriptorFilamin-B, ACETIC ACID (3 entities in total)
Functional Keywordsx-ray nesg hr5571a actin-binding domain, structural genomics, psi-2, protein structure initiative, northeast structural genomics consortium, actin-binding, alternative splicing, cytoplasm, cytoskeleton, developmental protein, differentiation, disease mutation, dwarfism, myogenesis, phosphoprotein, polymorphism, actin binding protein
Biological sourceHomo sapiens (human)
Cellular locationIsoform 1: Cytoplasm, cell cortex. Isoform 2: Cytoplasm, cytoskeleton. Isoform 3: Cytoplasm, cytoskeleton. Isoform 6: Cytoplasm, cytoskeleton O75369
Total number of polymer chains4
Total molecular weight122279.78
Authors
Primary citation
Kuzin, A.P.,Abashidze, M.,Seetharaman, R.,Shastry, R.,Sahdev, S.,Ciccosanti, C.,Xiao, R.,Everett, J.K.,Huang, Y.,Acton, T.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F.
Crystal structure of n-terminal actin-binding domain from human filamin b (tandem ch-domains). northeast structural genomics consortium target hr5571a.
To be Published,
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.268181.3%5.2%4.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3fer
no rotation
Molmil generated image of 3fer
rotated about x axis by 90°
Molmil generated image of 3fer
rotated about y axis by 90°