1YTY
 
 | | Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen | | 分子名称: | 5'-R(*UP*GP*CP*UP*GP*UP*UP*UP*U)-3', Lupus La protein | | 著者 | Teplova, M, Yuan, Y.R, Ilin, S, Malinina, L, Phan, A.T, Teplov, A, Patel, D.J. | | 登録日 | 2005-02-11 | | 公開日 | 2006-01-17 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Structural Basis for Recognition and Sequestration of UUU(OH) 3' Temini of Nascent RNA Polymerase III Transcripts by La, a Rheumatic Disease Autoantigen.
Mol.Cell, 21, 2006
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3KHH
 | | Dpo4 extension ternary complex with a C base opposite the 2-aminofluorene-guanine [AF]G lesion | | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-AMINOFLUORENE, 5'-D(*CP*CP*TP*A*AP*CP*GP*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', ... | | 著者 | Rechkoblit, O, Malinina, L, Patel, D.J. | | 登録日 | 2009-10-30 | | 公開日 | 2010-02-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Mechanism of error-free and semitargeted mutagenic bypass of an aromatic amine lesion by Y-family polymerase Dpo4.
Nat.Struct.Mol.Biol., 17, 2010
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8AQF
 | | CRYSTAL STRUCTURE OF HUMAN MONOGLYCERIDE LIPASE WITH COMPOUND LEI-515 | | 分子名称: | 1-[(~{R})-[2-chloranyl-4-[(2~{S},3~{S})-4-(3-chlorophenyl)-2,3-dimethyl-piperazin-1-yl]carbonyl-phenyl]sulfinyl]-3,3-bis(fluoranyl)pentan-2-one, Monoglyceride lipase | | 著者 | Jiang, M, Huizenga, M, Wirt, J, Paloczi, J, Amedi, A, van der Berg, R, Benz, J, Collin, L, Deng, H, Driever, W, Florea, B, Grether, U, Janssen, A, Heitman, L, Lam, T.W, Mohr, F, Pavlovic, A, Ruf, I, Rutjes, H, Stevens, F, van der Vliet, D, van der Wel, T, Wittwer, M, Boeckel, C, Pacher, P, Hohmann, A, van der Stelt, M. | | 登録日 | 2022-08-12 | | 公開日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Discovery of a peripheral restricted, reversible monoacylglycerol lipase inhibitor that reduces liver injury and chemotherapy-induced neuropathy
To Be Published
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8G4A
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8K8T
 | | Structure of CUL3-RBX1-KLHL22 complex | | 分子名称: | Cullin-3, Kelch-like protein 22 | | 著者 | Wang, W, Ling, L, Dai, Z, Zuo, P, Yin, Y. | | 登録日 | 2023-07-31 | | 公開日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3 KLHL22.
Nat Commun, 15, 2024
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8K9I
 | | Structure of CUL3-RBX1-KLHL22 complex without CUL3 NA motif | | 分子名称: | Cullin-3, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... | | 著者 | Wang, W, Ling, L, Dai, Z, Zuo, P, Yin, Y. | | 登録日 | 2023-08-01 | | 公開日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3 KLHL22.
Nat Commun, 15, 2024
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8BQY
 | | An i-motif domain able to undergo pH-dependent conformational transitions (acidic structure) | | 分子名称: | DNA (5'-D(*CP*(DNR)P*GP*TP*TP*(DNR)P*(DNR)P*GP*TP*TP*TP*TP*TP*CP*CP*GP*TP*TP*(DNR)P*CP*GP*T)-3') | | 著者 | Serrano-Chacon, I, Mir, B, Cupellini, L, Colizzi, F, Orozco, M, Escaja, N, Gonzalez, C. | | 登録日 | 2022-11-22 | | 公開日 | 2023-02-22 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | pH-Dependent Capping Interactions Induce Large-Scale Structural Transitions in i-Motifs.
J.Am.Chem.Soc., 145, 2023
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8BV6
 | | An i-motif domain able to undergo pH-dependent conformational transitions (neutral structure) | | 分子名称: | DNA (5'-D(*CP*(DNR)P*GP*TP*TP*CP*(DNR)P*GP*TP*TP*TP*TP*TP*CP*CP*GP*TP*TP*CP*CP*GP*T)-3') | | 著者 | Serrano-Chacon, I, Mir, B, Cupellini, L, Colizzi, F, Orozco, M, Escaja, N, Gonzalez, C. | | 登録日 | 2022-12-01 | | 公開日 | 2023-02-22 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | pH-Dependent Capping Interactions Induce Large-Scale Structural Transitions in i-Motifs.
J.Am.Chem.Soc., 145, 2023
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3KHG
 | | Dpo4 extension ternary complex with misinserted A opposite the 2-aminofluorene-guanine [AF]G lesion | | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-AMINOFLUORENE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | 著者 | Rechkoblit, O, Malinina, L, Patel, D.J. | | 登録日 | 2009-10-30 | | 公開日 | 2010-02-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.96 Å) | | 主引用文献 | Mechanism of error-free and semitargeted mutagenic bypass of an aromatic amine lesion by Y-family polymerase Dpo4.
Nat.Struct.Mol.Biol., 17, 2010
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3KHL
 | | Dpo4 post-extension ternary complex with misinserted A opposite the 2-aminofluorene-guanine [AF]G lesion | | 分子名称: | 2-AMINOFLUORENE, 5'-D(*CP*C*TP*AP*AP*CP*GP*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', 5'-D(*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*GP*AP*(DDG))-3', ... | | 著者 | Rechkoblit, O, Malinina, L, Patel, D.J. | | 登録日 | 2009-10-30 | | 公開日 | 2010-02-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Mechanism of error-free and semitargeted mutagenic bypass of an aromatic amine lesion by Y-family polymerase Dpo4.
Nat.Struct.Mol.Biol., 17, 2010
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3NEL
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3NEM
 | | Aspartyl-tRNA synthetase complexed with aspartyl adenylate | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ASPARTYL-ADENOSINE-5'-MONOPHOSPHATE, Aspartyl-tRNA synthetase, ... | | 著者 | Schmitt, E, Moras, D, Moulinier, L. | | 登録日 | 2010-06-09 | | 公開日 | 2010-08-04 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Crystal structure of aspartyl-tRNA synthetase from Pyrococcus kodakaraensis KOD: archaeon specificity and catalytic mechanism of adenylate formation
Embo J., 17, 1998
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3NEN
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3KHR
 | | Dpo4 post-extension ternary complex with the correct C opposite the 2-aminofluorene-guanine [AF]G lesion | | 分子名称: | 2-AMINOFLUORENE, 5'-D(*CP*C*TP*AP*AP*CP*GP*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', 5'-D(*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*GP*CP*(DDG))-3', ... | | 著者 | Rechkoblit, O, Malinina, L, Patel, D.J. | | 登録日 | 2009-10-30 | | 公開日 | 2010-02-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Mechanism of error-free and semitargeted mutagenic bypass of an aromatic amine lesion by Y-family polymerase Dpo4.
Nat.Struct.Mol.Biol., 17, 2010
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1VLX
 | | STRUCTURE OF ELECTRON TRANSFER (COBALT-PROTEIN) | | 分子名称: | AZURIN, COBALT (II) ION | | 著者 | Bonander, N, Vanngard, T, Tsai, L.-C, Langer, V, Nar, H, Sjolin, L. | | 登録日 | 1996-10-08 | | 公開日 | 1997-03-12 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The metal site of Pseudomonas aeruginosa azurin, revealed by a crystal structure determination of the Co(II) derivative and Co-EPR spectroscopy.
Proteins, 27, 1997
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8OGD
 | | Structure of zinc(II) double mutant human carbonic anhydrase II bound to thiocyanate | | 分子名称: | 4-(HYDROXYMERCURY)BENZOIC ACID, Carbonic anhydrase 2, THIOCYANATE ION, ... | | 著者 | Silva, J.M, Cerofolini, L, Carvalho, A.L, Ravera, E, Fragai, M, Parigi, G, Macedo, A.L, Geraldes, C.F.G.C, Luchinat, C. | | 登録日 | 2023-03-20 | | 公開日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Elucidating the concentration-dependent effects of thiocyanate binding to carbonic anhydrase.
J.Inorg.Biochem., 244, 2023
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8OGE
 | | Structure of cobalt(II) substituted double mutant human carbonic anhydrase II bound to thiocyanate | | 分子名称: | 4-(HYDROXYMERCURY)BENZOIC ACID, COBALT (II) ION, Carbonic anhydrase 2, ... | | 著者 | Silva, J.M, Cerofolini, L, Carvalho, A.L, Ravera, E, Fragai, M, Parigi, G, Macedo, A.L, Geraldes, C.F.G.C, Luchinat, C. | | 登録日 | 2023-03-20 | | 公開日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | | 主引用文献 | Elucidating the concentration-dependent effects of thiocyanate binding to carbonic anhydrase.
J.Inorg.Biochem., 244, 2023
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6IEJ
 | | The C2 domain of cytosolic phospholipase A2 alpha bound to phosphatidylcholine | | 分子名称: | 1,2-dihexanoyl-sn-glycero-3-phosphocholine, CALCIUM ION, Cytosolic phospholipase A2, ... | | 著者 | Hirano, Y, Gao, Y.G, Stephenson, D.J, Vu, N.T, Malinina, L, Chalfant, C.E, Patel, D.J, Brown, R.E. | | 登録日 | 2018-09-14 | | 公開日 | 2019-05-22 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.206 Å) | | 主引用文献 | Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase A2alpha.
Elife, 8, 2019
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6VAH
 | | Crystal structure of human TEAD2 transcription factor in complex with Flufenamic acid derivative | | 分子名称: | 2-fluoro-6-[(3-hexylphenyl)amino]benzoic acid, Transcriptional enhancer factor TEF-4, UNKNOWN ATOM OR ION | | 著者 | Halabelian, L, Zeng, H, Dong, A, Li, Y, Melin, L, Gagnon, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Santhakumar, V, Structural Genomics Consortium (SGC) | | 登録日 | 2019-12-17 | | 公開日 | 2020-04-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Crystal structure of human TEAD2 transcription factor in complex with Flufenamic acid derivative
to be published
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5FWQ
 | | Apo structure of human Leukotriene A4 hydrolase | | 分子名称: | ACETATE ION, HUMAN LEUKOTRIENE A4 HYDROLASE, IMIDAZOLE, ... | | 著者 | Wittmann, S.K, Kalinowsky, L, Kramer, J, Bloecher, R, Steinhilber, D, Pogoryelov, D, Proschak, E, Heering, J. | | 登録日 | 2016-02-19 | | 公開日 | 2016-10-05 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.047 Å) | | 主引用文献 | Thermodynamic properties of leukotriene A4hydrolase inhibitors.
Bioorg.Med.Chem., 24, 2016
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1XB8
 | | Zn substituted form of D62C/K74C double mutant of Pseudomonas Aeruginosa Azurin | | 分子名称: | Azurin, ZINC ION | | 著者 | Tigerstrom, A, Schwarz, F, Karlsson, G, Okvist, M, Alvarez-Rua, C, Maeder, D, Robb, F.T, Sjolin, L. | | 登録日 | 2004-08-30 | | 公開日 | 2004-10-19 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Effects of a novel disulfide bond and engineered electrostatic interactions on the thermostability of azurin
Biochemistry, 43, 2004
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1XB6
 | | The K24R mutant of Pseudomonas Aeruginosa Azurin | | 分子名称: | Azurin, COPPER (II) ION | | 著者 | Tigerstrom, A, Schwarz, F, Karlsson, G, Okvist, M, Alvarez-Rua, C, Maeder, D, Robb, F.T, Sjolin, L. | | 登録日 | 2004-08-30 | | 公開日 | 2004-10-19 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.823 Å) | | 主引用文献 | Effects of a novel disulfide bond and engineered electrostatic interactions on the thermostability of azurin
Biochemistry, 43, 2004
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1XB3
 | | The D62C/K74C double mutant of Pseudomonas Aeruginosa Azurin | | 分子名称: | Azurin, COPPER (II) ION | | 著者 | Tigerstrom, A, Schwarz, F, Karlsson, G, Okvist, M, Alvarez-Rua, C, Maeder, D, Robb, F.T, Sjolin, L. | | 登録日 | 2004-08-27 | | 公開日 | 2004-10-19 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.501 Å) | | 主引用文献 | Effects of a novel disulfide bond and engineered electrostatic interactions on the thermostability of azurin
Biochemistry, 43, 2004
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2VA1
 | | Crystal structure of UMP kinase from Ureaplasma parvum | | 分子名称: | PHOSPHATE ION, URIDYLATE KINASE | | 著者 | Egeblad-Welin, L, Welin, M, Wang, L, Eriksson, S. | | 登録日 | 2007-08-28 | | 公開日 | 2007-09-18 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural and Functional Investigations of Ureaplasma Parvum Ump Kinase - a Potential Antibacterial Drug Target
FEBS J., 274, 2007
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1YKQ
 | | Crystal structure of Diels-Alder ribozyme | | 分子名称: | CADMIUM ION, Diels-Alder ribozyme, MAGNESIUM ION | | 著者 | Serganov, A, Keiper, S, Malinina, L, Tereshko, V, Skripkin, E, Hobartner, C, Polonskaia, A, Phan, A.T, Wombacher, R, Micura, R, Dauter, Z, Jaschke, A, Patel, D.J. | | 登録日 | 2005-01-18 | | 公開日 | 2005-02-22 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation.
Nat.Struct.Mol.Biol., 12, 2005
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