8AQF

CRYSTAL STRUCTURE OF HUMAN MONOGLYCERIDE LIPASE WITH COMPOUND LEI-515

Summary for 8AQF

• Entry DOI: 10.2210/pdb8aqf/pdb
• Descriptor: Monoglyceride lipase, 1-[(~{R})-[2-chloranyl-4-[(2~{S},3~{S})-4-(3-chlorophenyl)-2,3-dimethyl-piperazin-1-yl]carbonyl-phenyl]sulfinyl]-3,3-bis(fluoranyl)pentan-2-one (3 entities in total)
• Functional Keywords: monoacylglycerol lipase, magl, inhibitor, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 35996.96

Authors

Jiang, M.,Huizenga, M.,Wirt, J.,Paloczi, J.,Amedi, A.,van der Berg, R.,Benz, J.,Collin, L.,Deng, H.,Driever, W.,Florea, B.,Grether, U.,Janssen, A.,Heitman, L.,Lam, T.W.,Mohr, F.,Pavlovic, A.,Ruf, I.,Rutjes, H.,Stevens, F.,van der Vliet, D.,van der Wel, T.,Wittwer, M.,Boeckel, C.,Pacher, P.,Hohmann, A.,van der Stelt, M. (deposition date: 2022-08-12, release date: 2023-08-23)

• Primary citation: Jiang, M.,van der Stelt, M.; Discovery of a peripheral restricted, reversible monoacylglycerol lipase inhibitor that reduces liver injury and chemotherapy-induced neuropathy; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.55 Å)