8OGE

Structure of cobalt(II) substituted double mutant human carbonic anhydrase II bound to thiocyanate

Summary for 8OGE

Entry DOI	10.2210/pdb8oge/pdb
Descriptor	Carbonic anhydrase 2, 4-(HYDROXYMERCURY)BENZOIC ACID, COBALT (II) ION, ... (5 entities in total)
Functional Keywords	inhibitor, thiocyanate, cobalt, metal binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	29696.70
Authors	Silva, J.M.,Cerofolini, L.,Carvalho, A.L.,Ravera, E.,Fragai, M.,Parigi, G.,Macedo, A.L.,Geraldes, C.F.G.C.,Luchinat, C. (deposition date: 2023-03-20, release date: 2024-02-07)
Primary citation	Silva, J.M.,Cerofolini, L.,Carvalho, A.L.,Ravera, E.,Fragai, M.,Parigi, G.,Macedo, A.L.,Geraldes, C.F.G.C.,Luchinat, C. Elucidating the concentration-dependent effects of thiocyanate binding to carbonic anhydrase. J.Inorg.Biochem., 244:112222-112222, 2023 Cited by PubMed: 37068394 DOI: 10.1016/j.jinorgbio.2023.112222 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.46 Å)

Structure validation