8G4A

Human ARNT PAS-B complexed with KG-548 small molecule

Summary for 8G4A

• Entry DOI: 10.2210/pdb8g4a/pdb
• Descriptor: Aryl hydrocarbon receptor nuclear translocator, 5-[3,5-bis(trifluoromethyl)phenyl]-2H-tetrazole (3 entities in total)
• Functional Keywords: inhibitor, transcription, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 28195.55

Authors

Xu, X.,Isiorho, E.A.,Pimentel Marcelino, L.,Gardner, K.H. (deposition date: 2023-02-08, release date: 2024-02-14, Last modification date: 2025-08-27)

• Primary citation: Gagne, D.,Azad, R.,Aramini, J.M.,Xu, X.,Isiorho, E.A.,Edupuganti, U.R.,Williams, J.,Marcelino, L.P.,Akasaka, K.,Gardner, K.H.; Use of High Pressure NMR Spectroscopy to Rapidly Identify Proteins with Internal Ligand-Binding Voids; Biorxiv, 2023; DOI: 10.1101/2020.08.25.267195

Experimental method

X-RAY DIFFRACTION (1.97 Å)