4WPE
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![BU of 4wpe by Molmil](/molmil-images/mine/4wpe) | Crystal Structure of Hof1p F-BAR domain | Descriptor: | Cytokinesis protein 2 | Authors: | Lemmon, M.A, Moravcevic, K. | Deposit date: | 2014-10-17 | Release date: | 2014-12-24 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Comparison of Saccharomyces cerevisiae F-BAR Domain Structures Reveals a Conserved Inositol Phosphate Binding Site. Structure, 23, 2015
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4WPC
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![BU of 4wpc by Molmil](/molmil-images/mine/4wpc) | |
7TVD
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![BU of 7tvd by Molmil](/molmil-images/mine/7tvd) | |
6VG3
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![BU of 6vg3 by Molmil](/molmil-images/mine/6vg3) | |
5JEB
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![BU of 5jeb by Molmil](/molmil-images/mine/5jeb) | |
1IHK
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![BU of 1ihk by Molmil](/molmil-images/mine/1ihk) | CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 9 (FGF9) | Descriptor: | GLIA-ACTIVATING FACTOR, PHOSPHATE ION | Authors: | Plotnikov, A.N, Eliseenkova, A.V, Ibrahimi, O.A, Lemmon, M.A, Mohammadi, M. | Deposit date: | 2001-04-19 | Release date: | 2001-05-02 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition. J.Biol.Chem., 276, 2001
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1MAI
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![BU of 1mai by Molmil](/molmil-images/mine/1mai) | STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM PHOSPHOLIPASE C DELTA IN COMPLEX WITH INOSITOL TRISPHOSPHATE | Descriptor: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, PHOSPHOLIPASE C DELTA-1 | Authors: | Ferguson, K.M, Lemmon, M.A, Schlessinger, J, Sigler, P.B. | Deposit date: | 1996-05-23 | Release date: | 1996-11-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain. Cell(Cambridge,Mass.), 83, 1995
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1NQL
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![BU of 1nql by Molmil](/molmil-images/mine/1nql) | |
5UTK
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![BU of 5utk by Molmil](/molmil-images/mine/5utk) | |
5WB8
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![BU of 5wb8 by Molmil](/molmil-images/mine/5wb8) | Crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, Epigen, ... | Authors: | Bessman, N.J, Freed, D.M, Moore, J.O, Ferguson, K.M, Lemmon, M.A. | Deposit date: | 2017-06-28 | Release date: | 2017-10-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics. Cell, 171, 2017
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5WB7
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![BU of 5wb7 by Molmil](/molmil-images/mine/5wb7) | Crystal structure of the epidermal growth factor receptor extracellular region in complex with epiregulin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ... | Authors: | Freed, D.M, Bessman, N.J, Ferguson, K.M, Lemmon, M.A. | Deposit date: | 2017-06-28 | Release date: | 2017-10-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.941 Å) | Cite: | EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics. Cell, 171, 2017
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1DYN
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![BU of 1dyn by Molmil](/molmil-images/mine/1dyn) | CRYSTAL STRUCTURE AT 2.2 ANGSTROMS RESOLUTION OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM HUMAN DYNAMIN | Descriptor: | DYNAMIN | Authors: | Ferguson, K.M, Lemmon, M.A, Schlessinger, J, Sigler, P.B. | Deposit date: | 1994-12-21 | Release date: | 1995-02-27 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin. Cell(Cambridge,Mass.), 79, 1994
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1FAO
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![BU of 1fao by Molmil](/molmil-images/mine/1fao) | STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH IN COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE | Descriptor: | DUAL ADAPTOR OF PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDES, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE | Authors: | Ferguson, K.M, Kavran, J.M, Sankaran, V.G, Fournier, E, Isakoff, S.J, Skolnik, E.Y, Lemmon, M.A. | Deposit date: | 2000-07-13 | Release date: | 2000-07-20 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. Mol.Cell, 6, 2000
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1FHX
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![BU of 1fhx by Molmil](/molmil-images/mine/1fhx) | Structure of the pleckstrin homology domain from GRP1 in complex with inositol 1,3,4,5-tetrakisphosphate | Descriptor: | GUANINE NUCLEOTIDE EXCHANGE FACTOR AND INTEGRIN BINDING PROTEIN HOMOLOG GRP1, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, SULFATE ION | Authors: | Ferguson, K.M, Kavran, J.M, Sankaran, V.G, Fournier, E, Isakoff, S.J, Skolnik, E.Y, Lemmon, M.A. | Deposit date: | 2000-08-02 | Release date: | 2000-08-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains Mol.Cell, 6, 2000
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1FB8
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![BU of 1fb8 by Molmil](/molmil-images/mine/1fb8) | STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH | Descriptor: | DUAL ADAPTOR OF PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDES, PHOSPHATE ION | Authors: | Ferguson, K.M, Kavran, J.M, Sankaran, V.G, Fournier, E, Isakoff, S.J, Skolnik, E.Y, Lemmon, M.A. | Deposit date: | 2000-07-14 | Release date: | 2000-07-20 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. Mol.Cell, 6, 2000
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1FHW
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![BU of 1fhw by Molmil](/molmil-images/mine/1fhw) | Structure of the pleckstrin homology domain from GRP1 in complex with inositol(1,3,4,5,6)pentakisphosphate | Descriptor: | GUANINE NUCLEOTIDE EXCHANGE FACTOR AND INTEGRIN BINDING PROTEIN HOMOLOG GRP1, INOSITOL-(1,3,4,5,6)-PENTAKISPHOSPHATE, SULFATE ION | Authors: | Ferguson, K.M, Kavran, J.M, Sankaran, V.G, Fournier, E, Isakoff, S.J, Skolnik, E.Y, Lemmon, M.A. | Deposit date: | 2000-08-02 | Release date: | 2000-08-23 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains Mol.Cell, 6, 2000
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7LEN
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![BU of 7len by Molmil](/molmil-images/mine/7len) | Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation in complex with epiregulin crystallized with trehalose | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Hu, C, Leche II, C.A, Stayrook, S.E, Ferguson, K.M, Lemmon, M.A. | Deposit date: | 2021-01-14 | Release date: | 2021-11-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias. Nature, 602, 2022
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7LFS
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![BU of 7lfs by Molmil](/molmil-images/mine/7lfs) | Crystal structure of the epidermal growth factor receptor extracellular region with A265V mutation in complex with epiregulin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 4 of Epidermal growth factor receptor, ... | Authors: | Hu, C, Leche II, C.A, Stayrook, S.E, Ferguson, K.M, Lemmon, M.A. | Deposit date: | 2021-01-18 | Release date: | 2021-11-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias. Nature, 602, 2022
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7LFR
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![BU of 7lfr by Molmil](/molmil-images/mine/7lfr) | Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation in complex with epiregulin crystallized with spermine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, Proepiregulin, ... | Authors: | Hu, C, Leche II, C.A, Stayrook, S.E, Ferguson, K.M, Lemmon, M.A. | Deposit date: | 2021-01-18 | Release date: | 2021-11-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias. Nature, 602, 2022
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7ME4
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![BU of 7me4 by Molmil](/molmil-images/mine/7me4) | Structure of the extracellular WNT-binding module in Drosophila Ror2/Nrk | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITOLEIC ACID, Tyrosine-protein kinase transmembrane receptor Ror2 | Authors: | Mendrola, J.M, Shi, F, Perry, K, Stayrook, S.E, Lemmon, M.A. | Deposit date: | 2021-04-06 | Release date: | 2021-10-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes. Cell Rep, 37, 2021
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7ME5
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![BU of 7me5 by Molmil](/molmil-images/mine/7me5) | Structure of the extracellular WNT-binding module in Drl-2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tyrosine-protein kinase transmembrane receptor DRL-2 | Authors: | Shi, F, Mendrola, J.M, Perry, K, Stayrook, S.E, Lemmon, M.A. | Deposit date: | 2021-04-06 | Release date: | 2021-10-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes. Cell Rep, 37, 2021
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3GOP
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![BU of 3gop by Molmil](/molmil-images/mine/3gop) | |
3I2T
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![BU of 3i2t by Molmil](/molmil-images/mine/3i2t) | Crystal structure of the unliganded Drosophila Epidermal Growth Factor Receptor ectodomain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ... | Authors: | Alvarado, D, Klein, D.E, Lemmon, M.A. | Deposit date: | 2009-06-29 | Release date: | 2009-09-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor. Nature, 461, 2009
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3LTG
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![BU of 3ltg by Molmil](/molmil-images/mine/3ltg) | |
3LMG
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![BU of 3lmg by Molmil](/molmil-images/mine/3lmg) | Crystal structure of the ERBB3 kinase domain in complex with AMP-PNP | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Receptor tyrosine-protein kinase erbB-3 | Authors: | Shi, F, Lemmon, M.A. | Deposit date: | 2010-01-30 | Release date: | 2010-04-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation. Proc.Natl.Acad.Sci.USA, 107, 2010
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