3GOP
Crystal structure of the EGF receptor juxtamembrane and kinase domains
Summary for 3GOP
Entry DOI | 10.2210/pdb3gop/pdb |
Descriptor | Epidermal growth factor receptor (2 entities in total) |
Functional Keywords | kinase, juxtamembrane, egfr, anti-oncogene, atp-binding, cell cycle, cell membrane, disease mutation, disulfide bond, glycoprotein, isopeptide bond, membrane, nucleotide-binding, phosphoprotein, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 1 |
Total formula weight | 41667.27 |
Authors | Choi, S.H.,Alvarado, D.,Moravcevic, K.,Lemmon, M.A. (deposition date: 2009-03-19, release date: 2009-07-07, Last modification date: 2023-09-06) |
Primary citation | Red Brewer, M.,Choi, S.H.,Alvarado, D.,Moravcevic, K.,Pozzi, A.,Lemmon, M.A.,Carpenter, G. The juxtamembrane region of the EGF receptor functions as an activation domain. Mol.Cell, 34:641-651, 2009 Cited by PubMed: 19560417DOI: 10.1016/j.molcel.2009.04.034 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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