3LTG

Crystal structure of the Drosophila Epidermal Growth Factor Receptor ectodomain complexed with a low affinity Spitz mutant

Summary for 3LTG

Entry DOI	10.2210/pdb3ltg/pdb
Related	3CA7 3I2T 3LTF
Descriptor	Epidermal growth factor receptor, Protein spitz (2 entities in total)
Functional Keywords	receptor-ligand complex ectodomain cysteine rich domain egf domain, atp-binding, kinase, nucleotide-binding, receptor, transferase, tyrosine-protein kinase, cell membrane, developmental protein, differentiation, disulfide bond, egf-like domain, endoplasmic reticulum, glycoprotein, golgi apparatus, membrane, neurogenesis, transmembrane, transferase-transferase regulator complex, transferase/transferase regulator
Biological source	Drosophila melanogaster More
Cellular location	Membrane; Single-pass type I membrane protein: P04412 Cell membrane; Single-pass type I membrane protein: Q01083
Total number of polymer chains	3
Total formula weight	141954.69
Authors	Alvarado, D.,Klein, D.E.,Lemmon, M.A. (deposition date: 2010-02-15, release date: 2010-08-25, Last modification date: 2023-09-06)
Primary citation	Alvarado, D.,Klein, D.E.,Lemmon, M.A. Structural basis for negative cooperativity in growth factor binding to an EGF receptor. Cell(Cambridge,Mass.), 142:568-579, 2010 Cited by PubMed: 20723758 DOI: 10.1016/j.cell.2010.07.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation