5WB8

Crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen

Summary for 5WB8

Entry DOI	10.2210/pdb5wb8/pdb
Descriptor	Epidermal growth factor receptor, Epigen, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	receptor tyrosine kinase, growth factor, signaling, membrane protein, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	129970.76
Authors	Bessman, N.J.,Freed, D.M.,Moore, J.O.,Ferguson, K.M.,Lemmon, M.A. (deposition date: 2017-06-28, release date: 2017-10-18, Last modification date: 2023-10-04)
Primary citation	Freed, D.M.,Bessman, N.J.,Kiyatkin, A.,Salazar-Cavazos, E.,Byrne, P.O.,Moore, J.O.,Valley, C.C.,Ferguson, K.M.,Leahy, D.J.,Lidke, D.S.,Lemmon, M.A. EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics. Cell, 171:683-695.e18, 2017 Cited by PubMed: 28988771 DOI: 10.1016/j.cell.2017.09.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation