5WB8

Crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	Epidermal growth factor receptor	polymer	507	56522.2	2	UniProt (P00533) Pfam (PF01030) Pfam (PF00757) In PDB	Homo sapiens (Human)	Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
2	B, C	Epigen	polymer	61	6865.7	2	UniProt (Q6UW88) In PDB	Homo sapiens (Human)	Epithelial mitogen,EPG
3	E, H, J	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
4	F, G	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
5	I	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
6		water	water		18.0	68	Chemie (HOH)

Sequence modifications

A, D: 1 - 501 (UniProt: P00533)

PDB	External Database	Details
His 502	-	expression tag
His 503	-	expression tag
His 504	-	expression tag
His 505	-	expression tag
His 506	-	expression tag
His 507	-	expression tag

B, C: 27 - 86 (UniProt: Q6UW88)

PDB	External Database	Details
Ser 26	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	126775.8
Branched	Number of molecules	6
	Total formula weight	3195.0
All*	Total formula weight	129970.8

*Water molecules are not included.