7TVD

Crystal structure of the kinase domain of EGFR exon-19 (del-747-749) mutant

Summary for 7TVD

Entry DOI	10.2210/pdb7tvd/pdb
Descriptor	Epidermal growth factor receptor (1 entity in total)
Functional Keywords	egfr, exon-19, kinase, oncoprotein, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	38237.19
Authors	Ashtekar, K.D.,Stayrook, S.E.,Lemmon, M.A. (deposition date: 2022-02-04, release date: 2022-02-16, Last modification date: 2023-10-25)
Primary citation	van Alderwerelt van Rosenburgh, I.K.,Lu, D.M.,Grant, M.J.,Stayrook, S.E.,Phadke, M.,Walther, Z.,Goldberg, S.B.,Politi, K.,Lemmon, M.A.,Ashtekar, K.D.,Tsutsui, Y. Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations. Nat Commun, 13:6791-6791, 2022 Cited by PubMed: 36357385 DOI: 10.1038/s41467-022-34398-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.96 Å)

Structure validation