7TVD

Crystal structure of the kinase domain of EGFR exon-19 (del-747-749) mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Epidermal growth factor receptor	polymer	335	38237.2	1	UniProt (P00533) Pfam (PF07714) In PDB	Homo sapiens (human)	Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1

Sequence modifications

A: 696 - 1022 (UniProt: P00533)

PDB	External Database	Details
Met 685	-	initiating methionine
Lys 686	-	expression tag
Lys 687	-	expression tag
Gly 688	-	expression tag
His 689	-	expression tag
His 690	-	expression tag
His 691	-	expression tag
His 692	-	expression tag
His 693	-	expression tag
His 694	-	expression tag
Gly 695	-	expression tag
-	Leu 747	deletion
-	Arg 748	deletion
-	Glu 749	deletion

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	38237.2
All*	Total formula weight	38237.2

*Water molecules are not included.