5JEB
Crystal structure of EGFR tyrosine kinase domain with novel inhibitor of active state of HER2
Summary for 5JEB
Entry DOI | 10.2210/pdb5jeb/pdb |
Descriptor | Epidermal growth factor receptor, SULFATE ION, 3-(furan-2-yl)-N-[5-(furan-2-yl)-2-methoxyphenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total) |
Functional Keywords | inhibitor, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 39122.07 |
Authors | Park, J.H.,Lemmon, M.A. (deposition date: 2016-04-18, release date: 2016-09-07, Last modification date: 2023-09-27) |
Primary citation | Novotny, C.J.,Pollari, S.,Park, J.H.,Lemmon, M.A.,Shen, W.,Shokat, K.M. Overcoming resistance to HER2 inhibitors through state-specific kinase binding. Nat.Chem.Biol., 12:923-930, 2016 Cited by PubMed: 27595329DOI: 10.1038/nchembio.2171 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.298 Å) |
Structure validation
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