5JEB
Crystal structure of EGFR tyrosine kinase domain with novel inhibitor of active state of HER2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 337 | 38556.6 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | B, C (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | D (A) | 3-(furan-2-yl)-N-[5-(furan-2-yl)-2-methoxyphenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine | non-polymer | 373.4 | 1 | Chemie (6JS) |
Sequence modifications
A: 672 - 998 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Met 662 | - | initiating methionine |
| Lys 663 | - | expression tag |
| Lys 664 | - | expression tag |
| Gly 665 | - | expression tag |
| His 666 | - | expression tag |
| His 667 | - | expression tag |
| His 668 | - | expression tag |
| His 669 | - | expression tag |
| His 670 | - | expression tag |
| Gly 671 | - | expression tag |
| Arg 924 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38556.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 565.5 | |
| All* | Total formula weight | 39122.1 |
