1FHX

Structure of the pleckstrin homology domain from GRP1 in complex with inositol 1,3,4,5-tetrakisphosphate

Summary for 1FHX

• Entry DOI: 10.2210/pdb1fhx/pdb
• Related: 1FHW
• Descriptor: GUANINE NUCLEOTIDE EXCHANGE FACTOR AND INTEGRIN BINDING PROTEIN HOMOLOG GRP1, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, SULFATE ION, ... (4 entities in total)
• Functional Keywords: pleckstrin, 3-phosphoinositides, inositol tetrakisphosphate signal transduction protein, guanine nucleotide exchange factor, signaling protein
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 2
• Total formula weight: 31912.46

Authors

Ferguson, K.M.,Kavran, J.M.,Sankaran, V.G.,Fournier, E.,Isakoff, S.J.,Skolnik, E.Y.,Lemmon, M.A. (deposition date: 2000-08-02, release date: 2000-08-23, Last modification date: 2023-11-15)

• Primary citation: Ferguson, K.M.,Kavran, J.M.,Sankaran, V.G.,Fournier, E.,Isakoff, S.J.,Skolnik, E.Y.,Lemmon, M.A.; Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains; Mol.Cell, 6:373-384, 2000; PubMed: 10983984; DOI: 10.1016/S1097-2765(00)00037-X

Experimental method

X-RAY DIFFRACTION (2.5 Å)