1NQL
Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF.
Summary for 1NQL
Entry DOI | 10.2210/pdb1nql/pdb |
Descriptor | epidermal growth factor receptor, epidermal growth factor, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | cell surface receptor, tyrosine kinase, glycoprotein, endosomal, growth factor, auto-inhibition, hormone-growth factor receptor complex, hormone/growth factor receptor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 78146.34 |
Authors | Ferguson, K.M.,Lemmon, M.A. (deposition date: 2003-01-21, release date: 2003-03-11, Last modification date: 2023-08-16) |
Primary citation | Ferguson, K.M.,Berger, M.B.,Mendrola, J.M.,Cho, H.,Leahy, D.J.,Lemmon, M.A. EGF activates its receptor by removing interactions that auto-inhibit ectodomain dimerization Mol.Cell, 11:507-517, 2003 Cited by PubMed: 12620237DOI: 10.1016/S1097-2765(03)00047-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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