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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1NQL

Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF.

Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CnCvvGyiGErC

Chain	Residue	Details
B	CYS31-CYS42

site_id	PS01186
Number of Residues	12
Details	EGF_2 EGF-like domain signature 2. CnCvvGYiger....C

Chain	Residue	Details
B	CYS31-CYS42

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:21487020

Chain	Residue	Details
A	SER205

site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; atypical; partial => ECO:0000269\|PubMed:10731668, ECO:0000269\|PubMed:12297049, ECO:0000269\|PubMed:12297050, ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:20837704, ECO:0007744\|PDB:1IVO, ECO:0007744\|PDB:1MOX, ECO:0007744\|PDB:3NJP, ECO:0007744\|PDB:3QWQ

Chain	Residue	Details
A	ASN32

site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; atypical => ECO:0000269\|PubMed:20837704, ECO:0007744\|PDB:3NJP

Chain	Residue	Details
A	ASN49

site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:8962717

Chain	Residue	Details
A	ASN104

site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:12297050, ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:20837704, ECO:0000269\|PubMed:8962717, ECO:0007744\|PDB:1IVO, ECO:0007744\|PDB:3NJP

Chain	Residue	Details
A	ASN151

site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:12297049, ECO:0000269\|PubMed:12297050, ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:20837704, ECO:0007744\|PDB:1IVO, ECO:0007744\|PDB:1MOX, ECO:0007744\|PDB:3NJP

Chain	Residue	Details
A	ASN172

site_id	SWS_FT_FI7
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:10731668, ECO:0000269\|PubMed:12297049, ECO:0000269\|PubMed:12297050, ECO:0000269\|PubMed:12620237, ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:20837704, ECO:0007744\|PDB:1IVO, ECO:0007744\|PDB:1MOX, ECO:0007744\|PDB:1NQL, ECO:0007744\|PDB:1YY9, ECO:0007744\|PDB:3B2U, ECO:0007744\|PDB:3B2V, ECO:0007744\|PDB:3NJP, ECO:0007744\|PDB:3P0Y, ECO:0007744\|PDB:3QWQ, ECO:0007744\|PDB:4KRL, ECO:0007744\|PDB:4KRM, ECO:0007744\|PDB:4KRO, ECO:0007744\|PDB:4KRP, ECO:0007744\|PDB:4UIP, ECO:0007744\|PDB:4UV7

Chain	Residue	Details
A	ASN328

site_id	SWS_FT_FI8
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:10731668, ECO:0000269\|PubMed:12297050, ECO:0000269\|PubMed:12620237, ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:20837704, ECO:0007744\|PDB:1IVO, ECO:0007744\|PDB:1NQL, ECO:0007744\|PDB:1YY9, ECO:0007744\|PDB:3B2U, ECO:0007744\|PDB:3NJP, ECO:0007744\|PDB:3QWQ, ECO:0007744\|PDB:4KRL, ECO:0007744\|PDB:4KRM, ECO:0007744\|PDB:4KRO, ECO:0007744\|PDB:4KRP, ECO:0007744\|PDB:4UV7

Chain	Residue	Details
A	ASN337

site_id	SWS_FT_FI9
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:8962717, ECO:0007744\|PDB:1YY9, ECO:0007744\|PDB:3B2U, ECO:0007744\|PDB:3B2V, ECO:0007744\|PDB:3P0Y, ECO:0007744\|PDB:3QWQ, ECO:0007744\|PDB:4KRO, ECO:0007744\|PDB:4KRP

Chain	Residue	Details
A	ASN389

site_id	SWS_FT_FI10
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:12297050, ECO:0000269\|PubMed:12620237, ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:20837704, ECO:0000269\|PubMed:8962717, ECO:0007744\|PDB:1IVO, ECO:0007744\|PDB:1NQL, ECO:0007744\|PDB:1YY9, ECO:0007744\|PDB:3B2U, ECO:0007744\|PDB:3B2V, ECO:0007744\|PDB:3NJP, ECO:0007744\|PDB:3P0Y, ECO:0007744\|PDB:3QWQ, ECO:0007744\|PDB:4KRL, ECO:0007744\|PDB:4KRM, ECO:0007744\|PDB:4KRO, ECO:0007744\|PDB:4KRP, ECO:0007744\|PDB:4UIP, ECO:0007744\|PDB:4UV7

Chain	Residue	Details
A	ASN420

site_id	SWS_FT_FI11
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:12620237, ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:20837704, ECO:0000269\|PubMed:25922362, ECO:0000269\|PubMed:8962717, ECO:0007744\|PDB:1NQL, ECO:0007744\|PDB:1YY9, ECO:0007744\|PDB:3B2V, ECO:0007744\|PDB:3NJP, ECO:0007744\|PDB:3QWQ, ECO:0007744\|PDB:4KRP, ECO:0007744\|PDB:4UIP, ECO:0007744\|PDB:4UV7

Chain	Residue	Details
A	ASN504

site_id	SWS_FT_FI12
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269\|PubMed:10731668, ECO:0000269\|PubMed:12620237, ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:19159218, ECO:0007744\|PDB:1NQL, ECO:0007744\|PDB:1YY9

Chain	Residue	Details
A	ASN544

site_id	SWS_FT_FI13
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269\|PubMed:10731668, ECO:0000269\|PubMed:12620237, ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0007744\|PDB:1NQL, ECO:0007744\|PDB:1YY9

Chain	Residue	Details
A	ASN579

site_id	SWS_FT_FI14
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000305\|PubMed:12731890

Chain	Residue	Details
A	ASN599

218500

PDB entries from 2024-04-17

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