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PDB: 35 件
4WPE
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BU of 4wpe by Molmil
Crystal Structure of Hof1p F-BAR domain
分子名称: Cytokinesis protein 2
著者Lemmon, M.A, Moravcevic, K.
登録日2014-10-17
公開日2014-12-24
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Comparison of Saccharomyces cerevisiae F-BAR Domain Structures Reveals a Conserved Inositol Phosphate Binding Site.
Structure, 23, 2015
5UTK
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BU of 5utk by Molmil
Crystal structure of the membrane proximal three fibronectin type III (FNIII) domains of Tie2 (Tie2[FNIIIa-c])
分子名称: Angiopoietin-1 receptor
著者Moore, J.O, Lemmon, M.A, Ferguson, K.M.
登録日2017-02-15
公開日2017-04-12
最終更新日2019-12-04
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Dimerization of Tie2 mediated by its membrane-proximal FNIII domains.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
7TVD
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BU of 7tvd by Molmil
Crystal structure of the kinase domain of EGFR exon-19 (del-747-749) mutant
分子名称: Epidermal growth factor receptor
著者Ashtekar, K.D, Stayrook, S.E, Lemmon, M.A.
登録日2022-02-04
公開日2022-02-16
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.96 Å)
主引用文献Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations.
Nat Commun, 13, 2022
5JEB
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BU of 5jeb by Molmil
Crystal structure of EGFR tyrosine kinase domain with novel inhibitor of active state of HER2
分子名称: 3-(furan-2-yl)-N-[5-(furan-2-yl)-2-methoxyphenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Epidermal growth factor receptor, SULFATE ION
著者Park, J.H, Lemmon, M.A.
登録日2016-04-18
公開日2016-09-07
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.298 Å)
主引用文献Overcoming resistance to HER2 inhibitors through state-specific kinase binding.
Nat.Chem.Biol., 12, 2016
1MAI
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BU of 1mai by Molmil
STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM PHOSPHOLIPASE C DELTA IN COMPLEX WITH INOSITOL TRISPHOSPHATE
分子名称: D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, PHOSPHOLIPASE C DELTA-1
著者Ferguson, K.M, Lemmon, M.A, Schlessinger, J, Sigler, P.B.
登録日1996-05-23
公開日1996-11-08
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain.
Cell(Cambridge,Mass.), 83, 1995
1NQL
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BU of 1nql by Molmil
Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Ferguson, K.M, Lemmon, M.A.
登録日2003-01-21
公開日2003-03-11
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献EGF activates its receptor by removing interactions that auto-inhibit ectodomain dimerization
Mol.Cell, 11, 2003
6VG3
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BU of 6vg3 by Molmil
Structure of unliganded, inactive PTK7 kinase domain
分子名称: Inactive tyrosine-protein kinase 7
著者Malhotra, K, Stayrook, S.E, Sheetz, J, Lemmon, M.A.
登録日2020-01-07
公開日2020-05-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural insights into receptor tyrosine kinase pseudokinase function
Mol.Cell, 2020
1DYN
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BU of 1dyn by Molmil
CRYSTAL STRUCTURE AT 2.2 ANGSTROMS RESOLUTION OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM HUMAN DYNAMIN
分子名称: DYNAMIN
著者Ferguson, K.M, Lemmon, M.A, Schlessinger, J, Sigler, P.B.
登録日1994-12-21
公開日1995-02-27
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin.
Cell(Cambridge,Mass.), 79, 1994
4WPC
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BU of 4wpc by Molmil
Crystal structure of Rgd1p F-BAR domain in complex with inositol phosphate
分子名称: INOSITOL HEXAKISPHOSPHATE, RHO GTPase-activating protein RGD1
著者Moravcevic, K, Lemmon, M.A.
登録日2014-10-17
公開日2014-12-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.34 Å)
主引用文献Comparison of Saccharomyces cerevisiae F-BAR Domain Structures Reveals a Conserved Inositol Phosphate Binding Site.
Structure, 23, 2015
5WB7
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BU of 5wb7 by Molmil
Crystal structure of the epidermal growth factor receptor extracellular region in complex with epiregulin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ...
著者Freed, D.M, Bessman, N.J, Ferguson, K.M, Lemmon, M.A.
登録日2017-06-28
公開日2017-10-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.941 Å)
主引用文献EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics.
Cell, 171, 2017
5WB8
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Crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, Epigen, ...
著者Bessman, N.J, Freed, D.M, Moore, J.O, Ferguson, K.M, Lemmon, M.A.
登録日2017-06-28
公開日2017-10-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics.
Cell, 171, 2017
1FHX
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BU of 1fhx by Molmil
Structure of the pleckstrin homology domain from GRP1 in complex with inositol 1,3,4,5-tetrakisphosphate
分子名称: GUANINE NUCLEOTIDE EXCHANGE FACTOR AND INTEGRIN BINDING PROTEIN HOMOLOG GRP1, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, SULFATE ION
著者Ferguson, K.M, Kavran, J.M, Sankaran, V.G, Fournier, E, Isakoff, S.J, Skolnik, E.Y, Lemmon, M.A.
登録日2000-08-02
公開日2000-08-23
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains
Mol.Cell, 6, 2000
1FB8
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BU of 1fb8 by Molmil
STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH
分子名称: DUAL ADAPTOR OF PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDES, PHOSPHATE ION
著者Ferguson, K.M, Kavran, J.M, Sankaran, V.G, Fournier, E, Isakoff, S.J, Skolnik, E.Y, Lemmon, M.A.
登録日2000-07-14
公開日2000-07-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains.
Mol.Cell, 6, 2000
1FHW
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Structure of the pleckstrin homology domain from GRP1 in complex with inositol(1,3,4,5,6)pentakisphosphate
分子名称: GUANINE NUCLEOTIDE EXCHANGE FACTOR AND INTEGRIN BINDING PROTEIN HOMOLOG GRP1, INOSITOL-(1,3,4,5,6)-PENTAKISPHOSPHATE, SULFATE ION
著者Ferguson, K.M, Kavran, J.M, Sankaran, V.G, Fournier, E, Isakoff, S.J, Skolnik, E.Y, Lemmon, M.A.
登録日2000-08-02
公開日2000-08-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains
Mol.Cell, 6, 2000
1FAO
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BU of 1fao by Molmil
STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH IN COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE
分子名称: DUAL ADAPTOR OF PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDES, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE
著者Ferguson, K.M, Kavran, J.M, Sankaran, V.G, Fournier, E, Isakoff, S.J, Skolnik, E.Y, Lemmon, M.A.
登録日2000-07-13
公開日2000-07-20
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains.
Mol.Cell, 6, 2000
1IHK
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BU of 1ihk by Molmil
CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 9 (FGF9)
分子名称: GLIA-ACTIVATING FACTOR, PHOSPHATE ION
著者Plotnikov, A.N, Eliseenkova, A.V, Ibrahimi, O.A, Lemmon, M.A, Mohammadi, M.
登録日2001-04-19
公開日2001-05-02
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition.
J.Biol.Chem., 276, 2001
7ME4
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BU of 7me4 by Molmil
Structure of the extracellular WNT-binding module in Drosophila Ror2/Nrk
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITOLEIC ACID, Tyrosine-protein kinase transmembrane receptor Ror2
著者Mendrola, J.M, Shi, F, Perry, K, Stayrook, S.E, Lemmon, M.A.
登録日2021-04-06
公開日2021-10-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes.
Cell Rep, 37, 2021
7ME5
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BU of 7me5 by Molmil
Structure of the extracellular WNT-binding module in Drl-2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Tyrosine-protein kinase transmembrane receptor DRL-2
著者Shi, F, Mendrola, J.M, Perry, K, Stayrook, S.E, Lemmon, M.A.
登録日2021-04-06
公開日2021-10-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes.
Cell Rep, 37, 2021
7LEN
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BU of 7len by Molmil
Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation in complex with epiregulin crystallized with trehalose
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Hu, C, Leche II, C.A, Stayrook, S.E, Ferguson, K.M, Lemmon, M.A.
登録日2021-01-14
公開日2021-11-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias.
Nature, 602, 2022
7LFS
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BU of 7lfs by Molmil
Crystal structure of the epidermal growth factor receptor extracellular region with A265V mutation in complex with epiregulin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 4 of Epidermal growth factor receptor, ...
著者Hu, C, Leche II, C.A, Stayrook, S.E, Ferguson, K.M, Lemmon, M.A.
登録日2021-01-18
公開日2021-11-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias.
Nature, 602, 2022
7LFR
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Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation in complex with epiregulin crystallized with spermine
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, Proepiregulin, ...
著者Hu, C, Leche II, C.A, Stayrook, S.E, Ferguson, K.M, Lemmon, M.A.
登録日2021-01-18
公開日2021-11-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias.
Nature, 602, 2022
3GOP
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BU of 3gop by Molmil
Crystal structure of the EGF receptor juxtamembrane and kinase domains
分子名称: Epidermal growth factor receptor
著者Choi, S.H, Alvarado, D, Moravcevic, K, Lemmon, M.A.
登録日2009-03-19
公開日2009-07-07
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The juxtamembrane region of the EGF receptor functions as an activation domain.
Mol.Cell, 34, 2009
3I2T
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BU of 3i2t by Molmil
Crystal structure of the unliganded Drosophila Epidermal Growth Factor Receptor ectodomain
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ...
著者Alvarado, D, Klein, D.E, Lemmon, M.A.
登録日2009-06-29
公開日2009-09-08
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor.
Nature, 461, 2009
3LTG
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BU of 3ltg by Molmil
Crystal structure of the Drosophila Epidermal Growth Factor Receptor ectodomain complexed with a low affinity Spitz mutant
分子名称: Epidermal growth factor receptor, Protein spitz
著者Alvarado, D, Klein, D.E, Lemmon, M.A.
登録日2010-02-15
公開日2010-08-25
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structural basis for negative cooperativity in growth factor binding to an EGF receptor.
Cell(Cambridge,Mass.), 142, 2010
3LMG
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BU of 3lmg by Molmil
Crystal structure of the ERBB3 kinase domain in complex with AMP-PNP
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Receptor tyrosine-protein kinase erbB-3
著者Shi, F, Lemmon, M.A.
登録日2010-01-30
公開日2010-04-21
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation.
Proc.Natl.Acad.Sci.USA, 107, 2010

 

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