1AYA
| |
4Z1G
| Crystal structure of human Trap1 with BIIB-021 | Descriptor: | 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-9H-purin-2-amine, Heat shock protein 75 kDa, mitochondrial | Authors: | Lee, C, Park, H.K, Ryu, J.H, Kang, B.H. | Deposit date: | 2015-03-27 | Release date: | 2015-04-22 | Last modified: | 2022-10-05 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1 J.Am.Chem.Soc., 137, 2015
|
|
6CNN
| |
6CNM
| Cryo-EM structure of the human SK4/calmodulin channel complex | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Calmodulin-1, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Lee, C.H, MacKinnon, R. | Deposit date: | 2018-03-08 | Release date: | 2018-05-02 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures. Science, 360, 2018
|
|
2Z9L
| |
2Z9G
| Complex structure of SARS-CoV 3C-like protease with PMA | Descriptor: | 3C-like proteinase, BENZENE, MERCURY (II) ION | Authors: | Lee, C.C, Wang, A.H. | Deposit date: | 2007-09-19 | Release date: | 2007-12-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors. Febs Lett., 581, 2007
|
|
2Z94
| Complex structure of SARS-CoV 3C-like protease with TDT | Descriptor: | 4-methylbenzene-1,2-dithiol, Replicase polyprotein 1ab, ZINC ION | Authors: | Lee, C.C, Wang, A.H. | Deposit date: | 2007-09-17 | Release date: | 2007-12-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors Febs Lett., 581, 2007
|
|
2Z9K
| Complex structure of SARS-CoV 3C-like protease with JMF1600 | Descriptor: | (dimethylamino)(hydroxy)zinc', 3C-like proteinase, DIMETHYL SULFOXIDE | Authors: | Lee, C.C, Wang, A.H. | Deposit date: | 2007-09-20 | Release date: | 2007-12-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors. Febs Lett., 581, 2007
|
|
2Z9J
| Complex structure of SARS-CoV 3C-like protease with EPDTC | Descriptor: | 3C-like proteinase, DIMETHYL SULFOXIDE, zinc(II)hydrogensulfide | Authors: | Lee, C.C, Wang, A.H. | Deposit date: | 2007-09-20 | Release date: | 2007-12-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors. Febs Lett., 581, 2007
|
|
3L9P
| |
7C8T
| Complex Structure of SARS-CoV-2 3CL Protease with TG-0205221 | Descriptor: | 3C-like proteinase, N-[(BENZYLOXY)CARBONYL]-O-(TERT-BUTYL)-L-THREONYL-3-CYCLOHEXYL-N-[(1S)-2-HYDROXY-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}ETHYL]-L-ALANINAMIDE | Authors: | Lee, C.C, Wang, A.H.J, Kuo, C.J, Liang, P.H. | Deposit date: | 2020-06-03 | Release date: | 2020-06-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Complex Structures and Cellular Activities of the Potent SARS-CoV-2 3CLpro Inhibitors Guiding Drug Discovery Against COVID-19 To Be Published
|
|
7C8R
| Complex Structure of SARS-CoV-2 3CL Protease with TG-0203770 | Descriptor: | 3C-like proteinase, ethyl (4R)-4-[[(2S)-4-methyl-2-[[(2S,3R)-3-[(2-methylpropan-2-yl)oxy]-2-(phenylmethoxycarbonylamino)butanoyl]amino]pentanoyl]amino]-5-[(3S)-2-oxidanylidenepyrrolidin-3-yl]pentanoate | Authors: | Lee, C.C, Wang, A.H.J, Kuo, C.J, Liang, P.H. | Deposit date: | 2020-06-03 | Release date: | 2020-06-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Complex Structures and Cellular Activities of the Potent SARS-CoV-2 3CLpro Inhibitors Guiding Drug Discovery Against COVID-19 To Be Published
|
|
1AYB
| |
5BZX
| Crystal structure of human phosphatase PTEN treated with a bisperoxovanadium complex | Descriptor: | L(+)-TARTARIC ACID, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, VANADATE ION | Authors: | Lee, C.-U, Bier, D, Hennig, S, Grossmann, T.N. | Deposit date: | 2015-06-11 | Release date: | 2015-10-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes. Angew.Chem.Int.Ed.Engl., 54, 2015
|
|
1AYD
| |
1J7J
| |
7CHY
| |
7CHZ
| |
5XHV
| Crystal Structure Of Fab S40 In Complex With Influenza Hemagglutinin, HA1 subunit. | Descriptor: | Hemagglutinin, S40 heavy chain, S40 light chain | Authors: | Lee, C.C, Wang, A.H.J, Yu, C.M, Yang, A.S. | Deposit date: | 2017-04-24 | Release date: | 2017-11-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | High throughput discovery of influenza virus neutralizing antibodies from phage-displayed synthetic antibody libraries. Sci Rep, 7, 2017
|
|
7CGA
| |
6JZL
| |
6CNO
| |
1X11
| X11 PTB DOMAIN | Descriptor: | 13-MER PEPTIDE, X11 | Authors: | Lee, C.-H, Zhang, Z, Kuriyan, J. | Deposit date: | 1997-07-28 | Release date: | 1998-01-14 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain. EMBO J., 16, 1997
|
|
5BUG
| Crystal structure of human phosphatase PTEN oxidized by H2O2 | Descriptor: | L(+)-TARTARIC ACID, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | Authors: | Lee, C.-U, Bier, D, Hennig, S, Grossmann, T.N. | Deposit date: | 2015-06-03 | Release date: | 2015-10-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes. Angew.Chem.Int.Ed.Engl., 54, 2015
|
|
5BZZ
| Crystal structure of human phosphatase PTEN in its reduced state | Descriptor: | L(+)-TARTARIC ACID, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | Authors: | Lee, C.-U, Bier, D, Hennig, S, Grossmann, T.N. | Deposit date: | 2015-06-11 | Release date: | 2015-10-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes. Angew.Chem.Int.Ed.Engl., 54, 2015
|
|