7CHZ

Crystal Structure Of Human Il-1beta In Complex With Antibody Binding Fragment Of IgG26A

Summary for 7CHZ

Entry DOI	10.2210/pdb7chz/pdb
Descriptor	light chain of antibody binding fragment of IgG26A, heavy chain of antibody binding fragment of IgG26A, Interleukin-1 beta, ... (4 entities in total)
Functional Keywords	complex, antibody, interleukin-1beta, immunosuppressant
Biological source	Homo sapiens More
Total number of polymer chains	3
Total formula weight	65595.66
Authors	Lee, C.C.,Wang, A.H.J.,Kuo, W.C. (deposition date: 2020-07-06, release date: 2021-01-13, Last modification date: 2023-11-29)
Primary citation	Kuo, W.C.,Lee, C.C.,Chang, Y.W.,Pang, W.,Chen, H.S.,Hou, S.C.,Lo, S.Y.,Yang, A.S.,Wang, A.H. Structure-based Development of Human Interleukin-1 beta-Specific Antibody That Simultaneously Inhibits Binding to Both IL-1RI and IL-1RAcP. J.Mol.Biol., 433:166766-166766, 2020 Cited by PubMed: 33359099 DOI: 10.1016/j.jmb.2020.166766 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation