7CHZ

Crystal Structure Of Human Il-1beta In Complex With Antibody Binding Fragment Of IgG26A

Functional Information from GO Data

Chain	GOid	namespace	contents
I	0005125	molecular_function	cytokine activity
I	0005615	cellular_component	extracellular space
I	0006954	biological_process	inflammatory response
I	0006955	biological_process	immune response

Functional Information from PROSITE/UniProt

site_id	PS00253
Number of Residues	21
Details	INTERLEUKIN_1 Interleukin-1 signature. FeSAqfPnwYISTsqaenmpV

Chain	Residue	Details
I	PHE229-VAL249

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR201-HIS207
L	TYR192-HIS198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	13
Details	Motif: {"description":"Involved in interaction with TMED10 C-terminus","evidences":[{"source":"PubMed","id":"32272059","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"Involved in receptor binding"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	5
Details	Site: {"description":"Important for interaction with integrin","evidences":[{"source":"PubMed","id":"29030430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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