2Z9K

Complex structure of SARS-CoV 3C-like protease with JMF1600

Summary for 2Z9K

Related2Z9G 2Z9J 2Z9L
Descriptor3C-like proteinase, DIMETHYL SULFOXIDE, (dimethylamino)(hydroxy)zinc', ... (4 entities in total)
Functional Keywordscomplex, atp-binding, cytoplasm, endonuclease, exonuclease, helicase, hydrolase, membrane, metal-binding, nuclease, nucleotide-binding, nucleotidyltransferase, protease, ribosomal frameshift, rna replication, rna-binding, rna-directed rna polymerase, thiol protease, transferase, transmembrane, zinc, zinc-finger
Biological sourceSARS coronavirus
Cellular locationNon-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity) P59641
Total number of polymer chains2
Total molecular weight68318.79
Authors
Lee, C.C.,Wang, A.H. (deposition date: 2007-09-20, release date: 2007-12-25, Last modification date: 2011-07-13)
Primary citation
Lee, C.C.,Kuo, C.J.,Hsu, M.F.,Liang, P.H.,Fang, J.M.,Shie, J.J.,Wang, A.H.
Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors.
Febs Lett., 581:5454-5458, 2007
PubMed: 17981158 (PDB entries with the same primary citation)
DOI: 10.1016/j.febslet.2007.10.048
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.85 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.222120.3%3.0%4.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution