4Z1G

Crystal structure of human Trap1 with BIIB-021

Summary for 4Z1G

Entry DOI	10.2210/pdb4z1g/pdb
Related	4z1f 4z1h 4z1i
Descriptor	Heat shock protein 75 kDa, mitochondrial, 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-9H-purin-2-amine (2 entities in total)
Functional Keywords	mitochondrial hsp90, chaperone
Biological source	Homo sapiens (Human)
Cellular location	Mitochondrion : Q12931
Total number of polymer chains	1
Total formula weight	57740.85
Authors	Lee, C.,Park, H.K.,Ryu, J.H.,Kang, B.H. (deposition date: 2015-03-27, release date: 2015-04-22, Last modification date: 2022-10-05)
Primary citation	Lee, C.,Park, H.K.,Jeong, H.,Lim, J.,Lee, A.J.,Cheon, K.Y.,Kim, C.S.,Thomas, A.P.,Bae, B.,Kim, N.D.,Kim, S.H.,Suh, P.G.,Ryu, J.H.,Kang, B.H. Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1 J.Am.Chem.Soc., 137:4358-4367, 2015 Cited by PubMed: 25785725 DOI: 10.1021/ja511893n PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation