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5BUG

Crystal structure of human phosphatase PTEN oxidized by H2O2

Summary for 5BUG
Entry DOI10.2210/pdb5bug/pdb
DescriptorPhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, L(+)-TARTARIC ACID (3 entities in total)
Functional Keywordshydrolase, c2 domain, disulfide, oxidized
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm. Isoform alpha: Secreted : P60484
Total number of polymer chains4
Total formula weight149831.57
Authors
Lee, C.-U.,Bier, D.,Hennig, S.,Grossmann, T.N. (deposition date: 2015-06-03, release date: 2015-10-07, Last modification date: 2024-01-10)
Primary citationLee, C.U.,Hahne, G.,Hanske, J.,Bange, T.,Bier, D.,Rademacher, C.,Hennig, S.,Grossmann, T.N.
Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes.
Angew.Chem.Int.Ed.Engl., 54:13796-13800, 2015
Cited by
PubMed: 26418532
DOI: 10.1002/anie.201506338
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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