Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016311 | biological_process | dephosphorylation |
| A | 0016791 | molecular_function | phosphatase activity |
| B | 0016311 | biological_process | dephosphorylation |
| B | 0016791 | molecular_function | phosphatase activity |
| C | 0016311 | biological_process | dephosphorylation |
| C | 0016791 | molecular_function | phosphatase activity |
| D | 0016311 | biological_process | dephosphorylation |
| D | 0016791 | molecular_function | phosphatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue TLA A 401 |
| Chain | Residue |
| A | ASP92 |
| A | THR131 |
| A | HOH544 |
| A | HOH561 |
| A | HOH574 |
| A | HIS93 |
| A | CYS124 |
| A | LYS125 |
| A | ALA126 |
| A | GLY127 |
| A | LYS128 |
| A | GLY129 |
| A | ARG130 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue TLA B 401 |
| Chain | Residue |
| B | ASP92 |
| B | CYS124 |
| B | LYS125 |
| B | ALA126 |
| B | GLY127 |
| B | LYS128 |
| B | GLY129 |
| B | ARG130 |
| B | THR131 |
| B | GLN171 |
| B | HOH564 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue TLA C 401 |
| Chain | Residue |
| C | ASP92 |
| C | HIS93 |
| C | LYS125 |
| C | ALA126 |
| C | GLY127 |
| C | LYS128 |
| C | GLY129 |
| C | ARG130 |
| C | THR131 |
| C | GLN171 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue TLA D 401 |
| Chain | Residue |
| D | ASP92 |
| D | HIS93 |
| D | CYS124 |
| D | LYS125 |
| D | ALA126 |
| D | GLY127 |
| D | LYS128 |
| D | GLY129 |
| D | ARG130 |
| D | THR131 |
| D | GLN171 |
| D | HOH503 |
| D | HOH513 |
Functional Information from PROSITE/UniProt
| site_id | PS00383 |
| Number of Residues | 11 |
| Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHCkaGkgRTG |
| Chain | Residue | Details |
| A | ILE122-GLY132 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 684 |
| Details | Domain: {"description":"Phosphatase tensin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00590","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | Region: {"description":"Required for interaction with NOP53","evidences":[{"source":"PubMed","id":"15355975","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00590","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"26166433","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphotyrosine; by FRK","evidences":[{"source":"PubMed","id":"19345329","evidenceCode":"ECO:0000269"}]} |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 456 |
| Chain | Residue | Details |
| A | ASP92 | proton shuttle (general acid/base) |
| A | CYS124 | covalent catalysis |
| A | ARG130 | transition state stabiliser |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 456 |
| Chain | Residue | Details |
| B | ASP92 | proton shuttle (general acid/base) |
| B | CYS124 | covalent catalysis |
| B | ARG130 | transition state stabiliser |
| site_id | MCSA3 |
| Number of Residues | 3 |
| Details | M-CSA 456 |
| Chain | Residue | Details |
| C | ASP92 | proton shuttle (general acid/base) |
| C | CYS124 | covalent catalysis |
| C | ARG130 | transition state stabiliser |
| site_id | MCSA4 |
| Number of Residues | 3 |
| Details | M-CSA 456 |
| Chain | Residue | Details |
| D | ASP92 | proton shuttle (general acid/base) |
| D | CYS124 | covalent catalysis |
| D | ARG130 | transition state stabiliser |
