7C8R

Complex Structure of SARS-CoV-2 3CL Protease with TG-0203770

Summary for 7C8R

• Entry DOI: 10.2210/pdb7c8r/pdb
• Descriptor: 3C-like proteinase, ethyl (4R)-4-[[(2S)-4-methyl-2-[[(2S,3R)-3-[(2-methylpropan-2-yl)oxy]-2-(phenylmethoxycarbonylamino)butanoyl]amino]pentanoyl]amino]-5-[(3S)-2-oxidanylidenepyrrolidin-3-yl]pentanoate (3 entities in total)
• Functional Keywords: inhibitor, complex, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• Total number of polymer chains: 1
• Total formula weight: 34458.33

Authors

Lee, C.C.,Wang, A.H.J.,Kuo, C.J.,Liang, P.H. (deposition date: 2020-06-03, release date: 2020-06-17, Last modification date: 2023-11-29)

• Primary citation: Kuo, C.J.,Shie, J.J.,Lin, C.H.,Lin, Y.L.,Hsieh, M.C.,Lee, C.C.,Chang, S.Y.,Wang, A.H.J.,Liang, P.H.; Complex Structures and Cellular Activities of the Potent SARS-CoV-2 3CLpro Inhibitors Guiding Drug Discovery Against COVID-19; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)