7U6M
 
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4TMK
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5TMP
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1TMK
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2TMK
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3QEN
 | | S74E dCK in complex with 5-bromodeoxycytidine and UDP | | 分子名称: | 5-bromo-2'-deoxycytidine, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE | | 著者 | Lavie, A, Hazra, S. | | 登録日 | 2011-01-20 | | 公開日 | 2011-03-16 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | | 主引用文献 | Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.
Biochemistry, 50, 2011
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3QEO
 | | S74E-R104M-D133A dCK variant in complex with L-deoxythymidine and UDP | | 分子名称: | Deoxycytidine kinase, L-deoxythymidine, URIDINE-5'-DIPHOSPHATE | | 著者 | Lavie, A, Hazra, S. | | 登録日 | 2011-01-20 | | 公開日 | 2011-03-16 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.897 Å) | | 主引用文献 | Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.
Biochemistry, 50, 2011
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1XYA
 | | X-RAY CRYSTALLOGRAPHIC STRUCTURES OF D-XYLOSE ISOMERASE-SUBSTRATE COMPLEXES POSITION THE SUBSTRATE AND PROVIDE EVIDENCE FOR METAL MOVEMENT DURING CATALYSIS | | 分子名称: | HYDROXIDE ION, MAGNESIUM ION, XYLOSE ISOMERASE | | 著者 | Lavie, A, Allen, K.N, Petsko, G.A, Ringe, D. | | 登録日 | 1994-01-03 | | 公開日 | 1994-05-31 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis.
Biochemistry, 33, 1994
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1XYB
 | | X-RAY CRYSTALLOGRAPHIC STRUCTURES OF D-XYLOSE ISOMERASE-SUBSTRATE COMPLEXES POSITION THE SUBSTRATE AND PROVIDE EVIDENCE FOR METAL MOVEMENT DURING CATALYSIS | | 分子名称: | D-glucose, MAGNESIUM ION, XYLOSE ISOMERASE | | 著者 | Lavie, A, Allen, K.N, Petsko, G.A, Ringe, D. | | 登録日 | 1994-01-03 | | 公開日 | 1994-05-31 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis.
Biochemistry, 33, 1994
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1XYC
 | | X-RAY CRYSTALLOGRAPHIC STRUCTURES OF D-XYLOSE ISOMERASE-SUBSTRATE COMPLEXES POSITION THE SUBSTRATE AND PROVIDE EVIDENCE FOR METAL MOVEMENT DURING CATALYSIS | | 分子名称: | 3-O-METHYLFRUCTOSE IN LINEAR FORM, MAGNESIUM ION, XYLOSE ISOMERASE | | 著者 | Lavie, A, Allen, K.N, Petsko, G.A, Ringe, D. | | 登録日 | 1994-01-03 | | 公開日 | 1994-05-31 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis.
Biochemistry, 33, 1994
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2RCZ
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3TMK
 | | CRYSTAL STRUCTURE OF YEAST THYMIDYLATE KINASE COMPLEXED WITH THE BISUBSTRATE INHIBITOR TP5A AT 2.0 A RESOLUTION: IMPLICATIONS FOR CATALYSIS AND AZT ACTIVATION | | 分子名称: | P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, THYMIDYLATE KINASE | | 著者 | Lavie, A, Schlichting, I, Konrad, M, Goody, R.S, Brundiers, R, Reinstein, J. | | 登録日 | 1998-01-26 | | 公開日 | 1999-02-16 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation.
Biochemistry, 37, 1998
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3MTR
 | | Crystal structure of the Ig5-FN1 tandem of human NCAM | | 分子名称: | Neural cell adhesion molecule 1, SULFATE ION | | 著者 | Lavie, A, Foley, D.A. | | 登録日 | 2010-04-30 | | 公開日 | 2010-06-23 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure and mutagenesis of neural cell adhesion molecule domains: evidence for flexibility in the placement of polysialic acid attachment sites
J.Biol.Chem., 285, 2010
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2A2Z
 | | Crystal Structure of human deoxycytidine kinase in complex with deoxycytidine and uridine diphosphate | | 分子名称: | 2'-DEOXYCYTIDINE, CALCIUM ION, Deoxycytidine kinase, ... | | 著者 | Godsey, M.H, Ort, S, Sabini, E, Konrad, M, Lavie, A. | | 登録日 | 2005-06-23 | | 公開日 | 2006-01-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (3.02 Å) | | 主引用文献 | Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: illuminating the role of main-chain reorganization.
Biochemistry, 45, 2006
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3KFX
 | | Human dCK complex with 5-Me dC and ADP | | 分子名称: | 5-METHYL-2'-DEOXYCYTIDINE, ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase | | 著者 | Hazra, S, Lavie, A. | | 登録日 | 2009-10-28 | | 公開日 | 2010-09-15 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues .
Biochemistry, 49, 2010
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2GYI
 | | DESIGN, SYNTHESIS, AND CHARACTERIZATION OF A POTENT XYLOSE ISOMERASE INHIBITOR, D-THREONOHYDROXAMIC ACID, AND HIGH-RESOLUTION X-RAY CRYSTALLOGRAPHIC STRUCTURE OF THE ENZYME-INHIBITOR COMPLEX | | 分子名称: | 2,3,4,N-TETRAHYDROXY-BUTYRIMIDIC ACID, MAGNESIUM ION, XYLOSE ISOMERASE | | 著者 | Allen, K.N, Lavie, A, Petsko, G.A, Ringe, D. | | 登録日 | 1994-09-01 | | 公開日 | 1995-07-10 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Design, Synthesis, and Characterization of a Potent Xylose Isomerase Inhibitor, D-Threonohydroxamic Acid, and High-Resolution X-Ray Crystallographic Structure of the Enzyme-Inhibitor Complex
Biochemistry, 34, 1995
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6VMZ
 | | Crystal Structure of a H5N1 influenza virus hemagglutinin with CBS1117 | | 分子名称: | 2,6-dichloro-N-[1-(propan-2-yl)piperidin-4-yl]benzamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin | | 著者 | Antanasijevic, A, Durst, M.A, Lavie, A, Caffrey, M. | | 登録日 | 2020-01-28 | | 公開日 | 2020-07-01 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure of avian influenza hemagglutinin in complex with a small molecule entry inhibitor.
Life Sci Alliance, 3, 2020
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6OC0
 | | Crystal structure of human DHODH with OSU-03012 | | 分子名称: | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ... | | 著者 | Durst, M.A, Lavie, A. | | 登録日 | 2019-03-21 | | 公開日 | 2019-11-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism.
Cell Chem Biol, 27, 2020
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4YYX
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2QQE
 | | Thymidine Kinase from Thermotoga Maritima in complex with Thymidine | | 分子名称: | THYMIDINE, Thymidine kinase, ZINC ION | | 著者 | Segura-Pena, D, Lichter, J, Trani, M, Konrad, M, Lavie, A, Lutz, S. | | 登録日 | 2007-07-26 | | 公開日 | 2007-10-16 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Quaternary structure change as a mechanism for the regulation of thymidine kinase 1-like enzymes.
Structure, 15, 2007
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2QJF
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1KGD
 | | Crystal Structure of the Guanylate Kinase-like Domain of Human CASK | | 分子名称: | FORMIC ACID, PERIPHERAL PLASMA MEMBRANE CASK | | 著者 | Li, Y, Spangenberg, O, Paarmann, I, Konrad, M, Lavie, A. | | 登録日 | 2001-11-26 | | 公開日 | 2001-12-19 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.314 Å) | | 主引用文献 | Structural basis for nucleotide-dependent regulation of membrane-associated guanylate kinase-like domains.
J.Biol.Chem., 277, 2002
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4R8K
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3HP1
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5W6O
 | | Choline Kinase Alpha in Complex with TCD-717 | | 分子名称: | 1,1'-[[1,1'-biphenyl]-4,4'-diylbis(methylene)]bis{4-[(4-chlorophenyl)(methyl)amino]quinolin-1-ium}, 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | | 著者 | Kall, S.K, Lavie, A. | | 登録日 | 2017-06-16 | | 公開日 | 2018-02-14 | | 最終更新日 | 2019-12-11 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Identification of a Unique Inhibitor-Binding Site on Choline Kinase alpha.
Biochemistry, 57, 2018
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