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PDB: 151 件
6D07
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BU of 6d07 by Molmil
Crystal structure of the complex between human chromobox homolog 1 (CBX1) and H3K9me3 peptide
分子名称: Chromobox protein homolog 1, GLYCEROL, Histone H3.1
著者Arora, S, Horne, W.S, Islam, K.
登録日2018-04-10
公開日2019-04-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Engineering Methyllysine Writers and Readers for Allele-Specific Regulation of Protein-Protein Interactions.
J.Am.Chem.Soc., 141, 2019
4Z84
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BU of 4z84 by Molmil
PKAB3 in complex with pyrrolidine inhibitor 34a
分子名称: 7-[(3S,4R)-4-(3-chlorophenyl)carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one, METHANOL, cAMP-dependent protein kinase catalytic subunit alpha, ...
著者Lund, B.A, Alam, K.A, Engh, R.A.
登録日2015-04-08
公開日2015-12-02
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.554 Å)
主引用文献Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic.
Chemistry, 22, 2016
4Z83
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BU of 4z83 by Molmil
PKAB3 in complex with pyrrolidine inhibitor 47a
分子名称: 7-{(3S,4R)-4-[(5-bromothiophen-2-yl)carbonyl]pyrrolidin-3-yl}quinazolin-4(3H)-one, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha
著者Lund, B.A, Alam, K.A, Engh, R.A.
登録日2015-04-08
公開日2015-12-02
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic.
Chemistry, 22, 2016
5BX6
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BU of 5bx6 by Molmil
PKA in complex with a halogenated phthalazinone fragment compound.
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 4-chlorophthalazin-1(2H)-one, cAMP-dependent protein kinase catalytic subunit alpha, ...
著者Narayanan, D, Alam, K.A, Engh, R.A.
登録日2015-06-08
公開日2016-09-14
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献PKA based studies of ligand interactions with a methionine gatekeeper.
To Be Published
2R8J
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BU of 2r8j by Molmil
Structure of the Eukaryotic DNA Polymerase eta in complex with 1,2-d(GpG)-cisplatin containing DNA
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, Cisplatin, ...
著者Carell, T, Alt, A, Lammens, K.
登録日2007-09-11
公開日2007-12-11
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta
Science, 318, 2007
2R8K
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BU of 2r8k by Molmil
Structure of the Eukaryotic DNA Polymerase eta in complex with 1,2-d(GpG)-cisplatin containing DNA
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-D(*DGP*DTP*DGP*DGP*DTP*DGP*DAP*DGP*DC)-3', 5'-D(P*DGP*DGP*DCP*DTP*DCP*DAP*DCP*DCP*DAP*DC)-3', ...
著者Carell, T, Alt, A, Lammens, K.
登録日2007-09-11
公開日2007-12-11
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta
Science, 318, 2007
7NI5
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BU of 7ni5 by Molmil
Human ATM kinase with bound inhibitor KU-55933
分子名称: 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, Serine-protein kinase ATM, ZINC ION
著者Bartho, J.D, Stakyte, K, Rotheneder, M, Lammens, K, Hopfner, K.P.
登録日2021-02-11
公開日2021-09-01
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (2.78 Å)
主引用文献Molecular basis of human ATM kinase inhibition.
Nat.Struct.Mol.Biol., 28, 2021
7NI6
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Human ATM kinase with bound ATPyS
分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine-protein kinase ATM, ...
著者Stakyte, K, Rotheneder, M, Lammens, K, Bartho, J.D.
登録日2021-02-11
公開日2021-09-01
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Molecular basis of human ATM kinase inhibition.
Nat.Struct.Mol.Biol., 28, 2021
3THO
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BU of 3tho by Molmil
Crystal structure of Mre11:Rad50 in its ATP/ADP bound state
分子名称: ADENOSINE-5'-DIPHOSPHATE, Exonuclease, putative, ...
著者Moeckel, C, Lammens, K.
登録日2011-08-19
公開日2011-10-12
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.6081 Å)
主引用文献ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex.
Nucleic Acids Res., 40, 2012
5BX7
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BU of 5bx7 by Molmil
PKA in complex with a benzothiophene fragment compound.
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1-benzothiophen-3-ylmethanol, ...
著者Narayanan, D, Alam, K.A, Engh, R.A.
登録日2015-06-08
公開日2016-09-14
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献PKA based studies of ligand interactions with a methionine gatekeeper.
To Be Published
9CKV
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BU of 9ckv by Molmil
Cryo-EM structure of alpha5beta1 integrin in complex with NeoNectin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Werther, R, Nguyen, A, Estrada Alamo, K.A, Wang, X, Campbell, M.G.
登録日2024-07-09
公開日2024-07-17
実験手法ELECTRON MICROSCOPY (3.19 Å)
主引用文献De Novo Design of Integrin alpha5beta1 Modulating Proteins for Regenerative Medicine
To Be Published
3THN
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BU of 3thn by Molmil
Crystal structure of Mre11 core with manganese
分子名称: Exonuclease, putative, MANGANESE (II) ION, ...
著者Moeckel, C, Lammens, K.
登録日2011-08-19
公開日2011-10-12
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.811 Å)
主引用文献ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex.
Nucleic Acids Res., 40, 2012
4FBK
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BU of 4fbk by Molmil
Crystal structure of a covalently fused Nbs1-Mre11 complex with one manganese ion per active site
分子名称: DNA repair and telomere maintenance protein nbs1,DNA repair protein rad32 CHIMERIC PROTEIN, MANGANESE (II) ION, SULFATE ION
著者Schiller, C.B, Lammens, K, Hopfner, K.P.
登録日2012-05-23
公開日2012-06-20
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.379 Å)
主引用文献Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.
Nat.Struct.Mol.Biol., 19, 2012
4FBQ
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BU of 4fbq by Molmil
Crystal structure of a covalently fused Nbs1-Mre11 complex with two manganese ions per active site
分子名称: DNA repair and telomere maintenance protein nbs1,DNA repair protein rad32 CHIMERIC PROTEIN, MANGANESE (II) ION
著者Schiller, C.B, Lammens, K, Hopfner, K.P.
登録日2012-05-23
公開日2012-06-20
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.
Nat.Struct.Mol.Biol., 19, 2012
4FCX
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BU of 4fcx by Molmil
S.pombe Mre11 apoenzym
分子名称: DNA repair protein rad32, MANGANESE (II) ION
著者Schiller, C.B, Lammens, K, Hopfner, K.P.
登録日2012-05-25
公開日2012-06-20
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.
Nat.Struct.Mol.Biol., 19, 2012
4FBW
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BU of 4fbw by Molmil
Crystal structure of an unfused Mre11-Nbs1 complex with two manganese ions per active site
分子名称: DNA repair and telomere maintenance protein nbs1, DNA repair protein rad32, MANGANESE (II) ION
著者Schiller, C.B, Lammens, K, Hopfner, K.P.
登録日2012-05-23
公開日2012-06-20
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.
Nat.Struct.Mol.Biol., 19, 2012
4I1P
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BU of 4i1p by Molmil
Human MALT1 (caspase-IG3) in complex with activity based-probe
分子名称: ACETATE ION, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, tetrapeptide
著者Schlauderer, F, Lammens, K, Hopfner, K.P.
登録日2012-11-21
公開日2014-07-09
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.403 Å)
主引用文献Activity-Based Probes for Detection of Active MALT1 Paracaspase in Immune Cells and Lymphomas.
Chem.Biol., 22, 2015
4I1R
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BU of 4i1r by Molmil
Human MALT1 (caspase-IG3) in complex with thioridazine
分子名称: 10-{2-[(2S)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine, Mucosa-associated lymphoid tissue lymphoma translocation protein 1
著者Schlauderer, F, Lammens, K, Hopfner, K.P.
登録日2012-11-21
公開日2013-08-28
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Analysis of Phenothiazine Derivatives as Allosteric Inhibitors of the MALT1 Paracaspase.
Angew.Chem.Int.Ed.Engl., 52, 2013
8BAH
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BU of 8bah by Molmil
Human Mre11-Nbs1 complex
分子名称: Double-strand break repair protein MRE11, MANGANESE (II) ION, Nibrin
著者Bartho, J.D, Rotheneder, M, Stakyte, K, Lammens, K, Hopfner, K.P.
登録日2022-10-11
公開日2023-01-11
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (4.13 Å)
主引用文献Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions.
Mol.Cell, 83, 2023
4I51
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BU of 4i51 by Molmil
Methyltransferase domain of HUMAN EUCHROMATIC HISTONE METHYLTRANSFERASE 1, mutant Y1211A
分子名称: GLYCEROL, H3K9 NE-ALLYL PEPTIDE, Histone-lysine N-methyltransferase EHMT1, ...
著者Dong, A, Zeng, H, Walker, J.R, Islam, K, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Lou, M, Min, J, Wu, H, Structural Genomics Consortium (SGC)
登録日2012-11-28
公開日2012-12-19
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation.
Proc.Natl.Acad.Sci.USA, 110, 2013
7Q3Z
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BU of 7q3z by Molmil
DNA/RNA binding protein
分子名称: SODIUM ION, Schlafen family member 5, ZINC ION
著者Huber, E, Lammens, K.
登録日2021-10-29
公開日2022-01-26
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural and biochemical characterization of human Schlafen 5.
Nucleic Acids Res., 50, 2022
3OYZ
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BU of 3oyz by Molmil
Haloferax volcanii Malate Synthase Pyruvate/Acetyl-CoA Ternary Complex
分子名称: ACETYL COENZYME *A, CHLORIDE ION, MAGNESIUM ION, ...
著者Howard, B.R, Bracken, C, Neighbor, A, Thomas, G, Lamlenn, K.K, Schubert, H.L, Whitby, F.G.
登録日2010-09-24
公開日2011-06-01
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structures of a halophilic archaeal malate synthase from Haloferax volcanii and comparisons with isoforms A and G.
Bmc Struct.Biol., 11, 2011
3PUG
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BU of 3pug by Molmil
Haloferax volcanii Malate Synthase Native at 3mM Glyoxylate
分子名称: CHLORIDE ION, GLYOXYLIC ACID, MAGNESIUM ION, ...
著者Howard, B.R, Bracken, C.D, Neighbor, A.M, Thomas, G.C, Lamlenn, K.K, Schubert, H.L, Whitby, F.G.
登録日2010-12-04
公開日2011-06-01
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structures of a halophilic archaeal malate synthase from Haloferax volcanii and comparisons with isoforms A and G.
Bmc Struct.Biol., 11, 2011
3QF7
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BU of 3qf7 by Molmil
The Mre11:Rad50 complex forms an ATP dependent molecular clamp in DNA double-strand break repair
分子名称: MAGNESIUM ION, Mre11, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Moeckel, C, Lammens, K.
登録日2011-01-21
公開日2011-04-20
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair.
Cell(Cambridge,Mass.), 145, 2011
3OYX
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BU of 3oyx by Molmil
Haloferax volcanii Malate Synthase Magnesium/Glyoxylate Complex
分子名称: CHLORIDE ION, GLYOXYLIC ACID, MAGNESIUM ION, ...
著者Howard, B.R, Bracken, C, Neighbor, A, Thomas, G, Lamlenn, K.K, Schubert, H.L, Whitby, F.G.
登録日2010-09-24
公開日2011-06-01
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Crystal structures of a halophilic archaeal malate synthase from Haloferax volcanii and comparisons with isoforms A and G.
Bmc Struct.Biol., 11, 2011

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