7NI5
Human ATM kinase with bound inhibitor KU-55933
Summary for 7NI5
Entry DOI | 10.2210/pdb7ni5/pdb |
Related | 7NI4 |
EMDB information | 12343 12345 12346 12347 12350 12351 |
Descriptor | Serine-protein kinase ATM, 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, ZINC ION (3 entities in total) |
Functional Keywords | kinase, inhibitor, dna damage response, cancer research, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 710105.00 |
Authors | Bartho, J.D.,Stakyte, K.,Rotheneder, M.,Lammens, K.,Hopfner, K.P. (deposition date: 2021-02-11, release date: 2021-09-01, Last modification date: 2024-07-10) |
Primary citation | Stakyte, K.,Rotheneder, M.,Lammens, K.,Bartho, J.D.,Gradler, U.,Fuchss, T.,Pehl, U.,Alt, A.,van de Logt, E.,Hopfner, K.P. Molecular basis of human ATM kinase inhibition. Nat.Struct.Mol.Biol., 28:789-798, 2021 Cited by PubMed: 34556870DOI: 10.1038/s41594-021-00654-x PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.78 Å) |
Structure validation
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