7NI5

Human ATM kinase with bound inhibitor KU-55933

Summary for 7NI5

Entry DOI	10.2210/pdb7ni5/pdb
Related	7NI4
EMDB information	12343 12345 12346 12347 12350 12351
Descriptor	Serine-protein kinase ATM, 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, ZINC ION (3 entities in total)
Functional Keywords	kinase, inhibitor, dna damage response, cancer research, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	710105.00
Authors	Bartho, J.D.,Stakyte, K.,Rotheneder, M.,Lammens, K.,Hopfner, K.P. (deposition date: 2021-02-11, release date: 2021-09-01, Last modification date: 2021-10-20)
Primary citation	Stakyte, K.,Rotheneder, M.,Lammens, K.,Bartho, J.D.,Gradler, U.,Fuchss, T.,Pehl, U.,Alt, A.,van de Logt, E.,Hopfner, K.P. Molecular basis of human ATM kinase inhibition. Nat.Struct.Mol.Biol., 28:789-798, 2021 Cited by PubMed: 34556870 DOI: 10.1038/s41594-021-00654-x PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.78 Å)

Structure validation