7NI5

Human ATM kinase with bound inhibitor KU-55933

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Serine-protein kinase ATM	polymer	3086	354526.2	2	UniProt (Q13315) Pfam (PF11640) Pfam (PF02259) Pfam (PF00454) Pfam (PF02260) In PDB	Homo sapiens (Human)	Ataxia telangiectasia mutated,A-T mutated
2	A, B	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	non-polymer		395.5	2	Chemie (UF8)
3	A, B	ZINC ION	non-polymer		65.4	4	Chemie (ZN)

Sequence modifications

A, B: 1 - 3056 (UniProt: Q13315)

PDB	External Database	Details
Met -29	-	initiating methionine
Asp -28	-	expression tag
Tyr -27	-	expression tag
Lys -26	-	expression tag
Asp -25	-	expression tag
Asp -24	-	expression tag
Asp -23	-	expression tag
Asp -22	-	expression tag
Lys -21	-	expression tag
Gly -20	-	expression tag
Thr -19	-	expression tag
Asp -18	-	expression tag
Tyr -17	-	expression tag
Lys -16	-	expression tag
Asp -15	-	expression tag
Asp -14	-	expression tag
Asp -13	-	expression tag
Asp -12	-	expression tag
Lys -11	-	expression tag
Ser -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
Leu -7	-	expression tag
Glu -6	-	expression tag
Val -5	-	expression tag
Leu -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
Pro 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	709052.4
Non-Polymers*	Number of molecules	6
	Total formula weight	1052.6
All*	Total formula weight	710105.0

*Water molecules are not included.