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7NI5

Human ATM kinase with bound inhibitor KU-55933

Functional Information from GO Data
ChainGOidnamespacecontents
A0000077biological_processDNA damage checkpoint signaling
A0000425biological_processpexophagy
A0000723biological_processtelomere maintenance
A0000724biological_processdouble-strand break repair via homologous recombination
A0000729biological_processDNA double-strand break processing
A0000781cellular_componentchromosome, telomeric region
A0001541biological_processovarian follicle development
A0001666biological_processresponse to hypoxia
A0001756biological_processsomitogenesis
A0002331biological_processpre-B cell allelic exclusion
A0002376biological_processimmune system process
A0003677molecular_functionDNA binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004676molecular_function3-phosphoinositide-dependent protein kinase activity
A0004677molecular_functionDNA-dependent protein kinase activity
A0004679molecular_functionAMP-activated protein kinase activity
A0004694molecular_functioneukaryotic translation initiation factor 2alpha kinase activity
A0004711molecular_functionribosomal protein S6 kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005777cellular_componentperoxisome
A0005782cellular_componentperoxisomal matrix
A0005813cellular_componentcentrosome
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006281biological_processDNA repair
A0006302biological_processdouble-strand break repair
A0006303biological_processdouble-strand break repair via nonhomologous end joining
A0006338biological_processchromatin remodeling
A0006468biological_processprotein phosphorylation
A0006974biological_processDNA damage response
A0006977biological_processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
A0007094biological_processmitotic spindle assembly checkpoint signaling
A0007095biological_processmitotic G2 DNA damage checkpoint signaling
A0007131biological_processreciprocal meiotic recombination
A0007140biological_processmale meiotic nuclear division
A0007143biological_processfemale meiotic nuclear division
A0007165biological_processsignal transduction
A0007292biological_processfemale gamete generation
A0007420biological_processbrain development
A0007507biological_processheart development
A0008340biological_processdetermination of adult lifespan
A0008585biological_processfemale gonad development
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0009791biological_processpost-embryonic development
A0010212biological_processresponse to ionizing radiation
A0010506biological_processregulation of autophagy
A0010628biological_processpositive regulation of gene expression
A0016301molecular_functionkinase activity
A0016303molecular_function1-phosphatidylinositol-3-kinase activity
A0018105biological_processpeptidyl-serine phosphorylation
A0030335biological_processpositive regulation of cell migration
A0030889biological_processnegative regulation of B cell proliferation
A0031410cellular_componentcytoplasmic vesicle
A0032210biological_processregulation of telomere maintenance via telomerase
A0032212biological_processpositive regulation of telomere maintenance via telomerase
A0033151biological_processV(D)J recombination
A0033554biological_processcellular response to stress
A0034614biological_processcellular response to reactive oxygen species
A0035175molecular_functionhistone H3S10 kinase activity
A0035264biological_processmulticellular organism growth
A0035402molecular_functionhistone H3T11 kinase activity
A0035403molecular_functionhistone H3T6 kinase activity
A0035861cellular_componentsite of double-strand break
A0035979molecular_functionhistone H2AXS139 kinase activity
A0036092biological_processphosphatidylinositol-3-phosphate biosynthetic process
A0036289biological_processpeptidyl-serine autophosphorylation
A0042159biological_processlipoprotein catabolic process
A0042770biological_processsignal transduction in response to DNA damage
A0042802molecular_functionidentical protein binding
A0042981biological_processregulation of apoptotic process
A0043065biological_processpositive regulation of apoptotic process
A0043231cellular_componentintracellular membrane-bounded organelle
A0043517biological_processpositive regulation of DNA damage response, signal transduction by p53 class mediator
A0043525biological_processpositive regulation of neuron apoptotic process
A0044022molecular_functionhistone H3S28 kinase activity
A0044023molecular_functionhistone H4S1 kinase activity
A0044024molecular_functionhistone H2AS1 kinase activity
A0044025molecular_functionhistone H2BS14 kinase activity
A0044877molecular_functionprotein-containing complex binding
A0045141biological_processmeiotic telomere clustering
A0045785biological_processpositive regulation of cell adhesion
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046777biological_processprotein autophosphorylation
A0048538biological_processthymus development
A0048599biological_processoocyte development
A0051402biological_processneuron apoptotic process
A0051726biological_processregulation of cell cycle
A0070192biological_processchromosome organization involved in meiotic cell cycle
A0071044biological_processhistone mRNA catabolic process
A0071300biological_processcellular response to retinoic acid
A0071479biological_processcellular response to ionizing radiation
A0071480biological_processcellular response to gamma radiation
A0071481biological_processcellular response to X-ray
A0071500biological_processcellular response to nitrosative stress
A0072354molecular_functionhistone H3T3 kinase activity
A0072371molecular_functionhistone H2AS121 kinase activity
A0072518molecular_functionRho-dependent protein serine/threonine kinase activity
A0080135biological_processregulation of cellular response to stress
A0090398biological_processcellular senescence
A0090399biological_processreplicative senescence
A0097694biological_processestablishment of RNA localization to telomere
A0097695biological_processestablishment of protein-containing complex localization to telomere
A0098850cellular_componentextrinsic component of synaptic vesicle membrane
A0106310molecular_functionprotein serine kinase activity
A0140823molecular_functionhistone H2BS36 kinase activity
A0140855molecular_functionhistone H3S57 kinase activity
A0140857molecular_functionhistone H3T45 kinase activity
A1900034biological_processregulation of cellular response to heat
A1901796biological_processregulation of signal transduction by p53 class mediator
A1903626biological_processpositive regulation of DNA catabolic process
A1903978biological_processregulation of microglial cell activation
A1904262biological_processnegative regulation of TORC1 signaling
A1904354biological_processnegative regulation of telomere capping
A1904358biological_processpositive regulation of telomere maintenance via telomere lengthening
A1904884biological_processpositive regulation of telomerase catalytic core complex assembly
A1990244molecular_functionhistone H2AT120 kinase activity
A1990391cellular_componentDNA repair complex
A2000785biological_processregulation of autophagosome assembly
B0000077biological_processDNA damage checkpoint signaling
B0000425biological_processpexophagy
B0000723biological_processtelomere maintenance
B0000724biological_processdouble-strand break repair via homologous recombination
B0000729biological_processDNA double-strand break processing
B0000781cellular_componentchromosome, telomeric region
B0001541biological_processovarian follicle development
B0001666biological_processresponse to hypoxia
B0001756biological_processsomitogenesis
B0002331biological_processpre-B cell allelic exclusion
B0002376biological_processimmune system process
B0003677molecular_functionDNA binding
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004676molecular_function3-phosphoinositide-dependent protein kinase activity
B0004677molecular_functionDNA-dependent protein kinase activity
B0004679molecular_functionAMP-activated protein kinase activity
B0004694molecular_functioneukaryotic translation initiation factor 2alpha kinase activity
B0004711molecular_functionribosomal protein S6 kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005777cellular_componentperoxisome
B0005782cellular_componentperoxisomal matrix
B0005813cellular_componentcentrosome
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0006281biological_processDNA repair
B0006302biological_processdouble-strand break repair
B0006303biological_processdouble-strand break repair via nonhomologous end joining
B0006338biological_processchromatin remodeling
B0006468biological_processprotein phosphorylation
B0006974biological_processDNA damage response
B0006977biological_processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
B0007094biological_processmitotic spindle assembly checkpoint signaling
B0007095biological_processmitotic G2 DNA damage checkpoint signaling
B0007131biological_processreciprocal meiotic recombination
B0007140biological_processmale meiotic nuclear division
B0007143biological_processfemale meiotic nuclear division
B0007165biological_processsignal transduction
B0007292biological_processfemale gamete generation
B0007420biological_processbrain development
B0007507biological_processheart development
B0008340biological_processdetermination of adult lifespan
B0008585biological_processfemale gonad development
B0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
B0009791biological_processpost-embryonic development
B0010212biological_processresponse to ionizing radiation
B0010506biological_processregulation of autophagy
B0010628biological_processpositive regulation of gene expression
B0016301molecular_functionkinase activity
B0016303molecular_function1-phosphatidylinositol-3-kinase activity
B0018105biological_processpeptidyl-serine phosphorylation
B0030335biological_processpositive regulation of cell migration
B0030889biological_processnegative regulation of B cell proliferation
B0031410cellular_componentcytoplasmic vesicle
B0032210biological_processregulation of telomere maintenance via telomerase
B0032212biological_processpositive regulation of telomere maintenance via telomerase
B0033151biological_processV(D)J recombination
B0033554biological_processcellular response to stress
B0034614biological_processcellular response to reactive oxygen species
B0035175molecular_functionhistone H3S10 kinase activity
B0035264biological_processmulticellular organism growth
B0035402molecular_functionhistone H3T11 kinase activity
B0035403molecular_functionhistone H3T6 kinase activity
B0035861cellular_componentsite of double-strand break
B0035979molecular_functionhistone H2AXS139 kinase activity
B0036092biological_processphosphatidylinositol-3-phosphate biosynthetic process
B0036289biological_processpeptidyl-serine autophosphorylation
B0042159biological_processlipoprotein catabolic process
B0042770biological_processsignal transduction in response to DNA damage
B0042802molecular_functionidentical protein binding
B0042981biological_processregulation of apoptotic process
B0043065biological_processpositive regulation of apoptotic process
B0043231cellular_componentintracellular membrane-bounded organelle
B0043517biological_processpositive regulation of DNA damage response, signal transduction by p53 class mediator
B0043525biological_processpositive regulation of neuron apoptotic process
B0044022molecular_functionhistone H3S28 kinase activity
B0044023molecular_functionhistone H4S1 kinase activity
B0044024molecular_functionhistone H2AS1 kinase activity
B0044025molecular_functionhistone H2BS14 kinase activity
B0044877molecular_functionprotein-containing complex binding
B0045141biological_processmeiotic telomere clustering
B0045785biological_processpositive regulation of cell adhesion
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046777biological_processprotein autophosphorylation
B0048538biological_processthymus development
B0048599biological_processoocyte development
B0051402biological_processneuron apoptotic process
B0051726biological_processregulation of cell cycle
B0070192biological_processchromosome organization involved in meiotic cell cycle
B0071044biological_processhistone mRNA catabolic process
B0071300biological_processcellular response to retinoic acid
B0071479biological_processcellular response to ionizing radiation
B0071480biological_processcellular response to gamma radiation
B0071481biological_processcellular response to X-ray
B0071500biological_processcellular response to nitrosative stress
B0072354molecular_functionhistone H3T3 kinase activity
B0072371molecular_functionhistone H2AS121 kinase activity
B0072518molecular_functionRho-dependent protein serine/threonine kinase activity
B0080135biological_processregulation of cellular response to stress
B0090398biological_processcellular senescence
B0090399biological_processreplicative senescence
B0097694biological_processestablishment of RNA localization to telomere
B0097695biological_processestablishment of protein-containing complex localization to telomere
B0098850cellular_componentextrinsic component of synaptic vesicle membrane
B0106310molecular_functionprotein serine kinase activity
B0140823molecular_functionhistone H2BS36 kinase activity
B0140855molecular_functionhistone H3S57 kinase activity
B0140857molecular_functionhistone H3T45 kinase activity
B1900034biological_processregulation of cellular response to heat
B1901796biological_processregulation of signal transduction by p53 class mediator
B1903626biological_processpositive regulation of DNA catabolic process
B1903978biological_processregulation of microglial cell activation
B1904262biological_processnegative regulation of TORC1 signaling
B1904354biological_processnegative regulation of telomere capping
B1904358biological_processpositive regulation of telomere maintenance via telomere lengthening
B1904884biological_processpositive regulation of telomerase catalytic core complex assembly
B1990244molecular_functionhistone H2AT120 kinase activity
B1990391cellular_componentDNA repair complex
B2000785biological_processregulation of autophagosome assembly
Functional Information from PROSITE/UniProt
site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. VKgr.DDLRQDavmqQ
ChainResidueDetails
AVAL2716-GLN2730

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SvAtssIvgYILgLgDRHvqN
ChainResidueDetails
ASER2855-ASN2875

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N-acetylserine => ECO:0007744|PubMed:22223895
ChainResidueDetails
ASER2
BSER2

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:16858402
ChainResidueDetails
ASER367
ASER1893
BSER367
BSER1893

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16141325, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:30944854, ECO:0007744|PubMed:17525332
ChainResidueDetails
ASER1981
BSER1981

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17525332
ChainResidueDetails
ASER1983
BSER1983

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195
ChainResidueDetails
ASER2996
BSER2996

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:30944854
ChainResidueDetails
ALYS3016
BLYS3016

227561

PDB entries from 2024-11-20

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