7NI4
Human ATM kinase domain with bound M4076 inhibitor
Summary for 7NI4
Entry DOI | 10.2210/pdb7ni4/pdb |
EMDB information | 12343 12345 12346 12347 12350 |
Descriptor | Serine-protein kinase ATM, ZINC ION, 8-(1,3-dimethylpyrazol-4-yl)-1-(3-fluoranyl-5-methoxy-pyridin-4-yl)-7-methoxy-3-methyl-imidazo[4,5-c]quinolin-2-one (3 entities in total) |
Functional Keywords | kinase, inhibitor, dna damage response, cancer research, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 703283.09 |
Authors | Stakyte, K.,Rotheneder, M. (deposition date: 2021-02-11, release date: 2021-09-01, Last modification date: 2024-07-10) |
Primary citation | Stakyte, K.,Rotheneder, M.,Lammens, K.,Bartho, J.D.,Gradler, U.,Fuchss, T.,Pehl, U.,Alt, A.,van de Logt, E.,Hopfner, K.P. Molecular basis of human ATM kinase inhibition. Nat.Struct.Mol.Biol., 28:789-798, 2021 Cited by PubMed: 34556870DOI: 10.1038/s41594-021-00654-x PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3 Å) |
Structure validation
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