7NI4

Human ATM kinase domain with bound M4076 inhibitor

Summary for 7NI4

Entry DOI	10.2210/pdb7ni4/pdb
EMDB information	12343 12345 12346 12347 12350
Descriptor	Serine-protein kinase ATM, ZINC ION, 8-(1,3-dimethylpyrazol-4-yl)-1-(3-fluoranyl-5-methoxy-pyridin-4-yl)-7-methoxy-3-methyl-imidazo[4,5-c]quinolin-2-one (3 entities in total)
Functional Keywords	kinase, inhibitor, dna damage response, cancer research, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	703283.09
Authors	Stakyte, K.,Rotheneder, M. (deposition date: 2021-02-11, release date: 2021-09-01, Last modification date: 2024-07-10)
Primary citation	Stakyte, K.,Rotheneder, M.,Lammens, K.,Bartho, J.D.,Gradler, U.,Fuchss, T.,Pehl, U.,Alt, A.,van de Logt, E.,Hopfner, K.P. Molecular basis of human ATM kinase inhibition. Nat.Struct.Mol.Biol., 28:789-798, 2021 Cited by PubMed: 34556870 DOI: 10.1038/s41594-021-00654-x PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3 Å)

Structure validation