5BX6
PKA in complex with a halogenated phthalazinone fragment compound.
Summary for 5BX6
Entry DOI | 10.2210/pdb5bx6/pdb |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 4-chlorophthalazin-1(2H)-one, ... (5 entities in total) |
Functional Keywords | inhibitor, protein kinase, structure-guided, fragment-based, transferase |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm. Isoform 2: Cell projection, cilium, flagellum: P17612 |
Total number of polymer chains | 2 |
Total formula weight | 43650.07 |
Authors | Narayanan, D.,Alam, K.A.,Engh, R.A. (deposition date: 2015-06-08, release date: 2016-09-14, Last modification date: 2024-01-10) |
Primary citation | Narayanan, D.,Gani, O.A.,Alam, K.A.,Engh, R.A. PKA based studies of ligand interactions with a methionine gatekeeper. To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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