2R8J
Structure of the Eukaryotic DNA Polymerase eta in complex with 1,2-d(GpG)-cisplatin containing DNA
Summary for 2R8J
Entry DOI | 10.2210/pdb2r8j/pdb |
Related | 1JIH 2R8K |
Descriptor | DNA (5'-D(*DGP*DTP*DGP*DGP*DAP*DTP*DGP*DAP*DG)-3'), DNA (5'-D(P*DGP*DGP*DCP*DTP*DCP*DAP*DTP*DCP*DCP*DAP*DC)-3'), DNA polymerase eta, ... (7 entities in total) |
Functional Keywords | protein-cisplatin-dna-dntp complex, replication, transferase-dna complex, transferase/dna |
Biological source | Saccharomyces cerevisiae (baker's yeast) |
Cellular location | Nucleus: Q04049 |
Total number of polymer chains | 6 |
Total formula weight | 139190.34 |
Authors | Carell, T.,Alt, A.,Lammens, K. (deposition date: 2007-09-11, release date: 2007-12-11, Last modification date: 2023-08-30) |
Primary citation | Alt, A.,Lammens, K.,Chiocchini, C.,Lammens, A.,Pieck, J.C.,Kuch, D.,Hopfner, K.P.,Carell, T. Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta Science, 318:967-970, 2007 Cited by PubMed: 17991862DOI: 10.1126/science.1148242 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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