2R8J

Structure of the Eukaryotic DNA Polymerase eta in complex with 1,2-d(GpG)-cisplatin containing DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (Q, P)	DNA (5'-D(*DGP*DTP*DGP*DGP*DAP*DTP*DGP*DAP*DG)-3')	polymer	9	2835.9	2
2	B, D (U, T)	DNA (5'-D(P*DGP*DGP*DCP*DTP*DCP*DAP*DTP*DCP*DCP*DAP*DC)-3')	polymer	11	3294.2	2
3	E, F (A, B)	DNA polymerase eta	polymer	554	62617.8	2	UniProt (Q04049) Pfam (PF00817) Pfam (PF11799)	Saccharomyces cerevisiae (baker's yeast)	Radiation sensitive protein 30
4	G, H (U, T)	Cisplatin	non-polymer		300.0	2	Chemie (CPT)
5	I, J, L, M (A, B)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
6	K, N (A, B)	2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE	non-polymer		467.2	2	Chemie (DCP)
7	O, P, Q, R, S... (Q, U, P, T, A...)	water	water		18.0	121	Chemie (HOH)

Sequence modifications

A, B: 1 - 531 (UniProt: Q04049)

PDB	External Database	Details
Met -22	-	expression tag
Ala -21	-	expression tag
Ser -20	-	expression tag
Trp -19	-	expression tag
Ser -18	-	expression tag
His -17	-	expression tag
Pro -16	-	expression tag
Gln -15	-	expression tag
Phe -14	-	expression tag
Glu -13	-	expression tag
Lys -12	-	expression tag
Gly -11	-	expression tag
Ala -10	-	expression tag
Ser -9	-	expression tag
Thr -8	-	expression tag
Ser -7	-	expression tag
Leu -6	-	expression tag
Tyr -5	-	expression tag
Lys -4	-	expression tag
Lys -3	-	expression tag
Ala -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	137495.6
Non-Polymers*	Number of molecules	8
	Total formula weight	1694.7
All*	Total formula weight	139190.3

*Water molecules are not included.