4Z84
PKAB3 in complex with pyrrolidine inhibitor 34a
Summary for 4Z84
Entry DOI | 10.2210/pdb4z84/pdb |
Related | 1Q61 4Z83 |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 7-[(3S,4R)-4-(3-chlorophenyl)carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one, ... (5 entities in total) |
Functional Keywords | inhibitor, protein kinase, structure-guided, transferase |
Biological source | Bos taurus (Bovine) More |
Cellular location | Cytoplasm : P00517 |
Total number of polymer chains | 2 |
Total formula weight | 43472.94 |
Authors | Lund, B.A.,Alam, K.A.,Engh, R.A. (deposition date: 2015-04-08, release date: 2015-12-02, Last modification date: 2024-01-10) |
Primary citation | Lauber, B.S.,Hardegger, L.A.,Asraful, A.K.,Lund, B.A.,Dumele, O.,Harder, M.,Kuhn, B.,Engh, R.A.,Diederich, F. Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic. Chemistry, 22:211-221, 2016 Cited by PubMed: 26578105DOI: 10.1002/chem.201503552 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.554 Å) |
Structure validation
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