4I1R
Human MALT1 (caspase-IG3) in complex with thioridazine
Summary for 4I1R
Entry DOI | 10.2210/pdb4i1r/pdb |
Related | 4I1P |
Descriptor | Mucosa-associated lymphoid tissue lymphoma translocation protein 1, 10-{2-[(2S)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine (3 entities in total) |
Functional Keywords | protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, perinuclear region: Q9UDY8 |
Total number of polymer chains | 1 |
Total formula weight | 44560.39 |
Authors | Schlauderer, F.,Lammens, K.,Hopfner, K.P. (deposition date: 2012-11-21, release date: 2013-08-28, Last modification date: 2024-02-28) |
Primary citation | Schlauderer, F.,Lammens, K.,Nagel, D.,Vincendeau, M.,Eitelhuber, A.C.,Verhelst, S.H.,Kling, D.,Chrusciel, A.,Ruland, J.,Krappmann, D.,Hopfner, K.P. Structural Analysis of Phenothiazine Derivatives as Allosteric Inhibitors of the MALT1 Paracaspase. Angew.Chem.Int.Ed.Engl., 52:10384-10387, 2013 Cited by PubMed: 23946259DOI: 10.1002/anie.201304290 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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