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PDB: 91 件
1FBC
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CRYSTALLOGRAPHIC STUDIES OF THE CATALYTIC MECHANISM OF THE NEUTRAL FORM OF FRUCTOSE-1,6-BISPHOSPHATASE
分子名称: 2,5-anhydro-1,6-di-O-phosphono-D-glucitol, FRUCTOSE 1,6-BISPHOSPHATASE, MAGNESIUM ION
著者Zhang, Y, Liang, J.-Y, Huang, S, Ke, H, Lipscomb, W.N.
登録日1992-10-14
公開日1993-10-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase.
Biochemistry, 32, 1993
2CYH
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CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE ALA-PRO
分子名称: ALANINE, CYCLOPHILIN A, PROLINE
著者Zhao, Y, Ke, H.
登録日1996-02-27
公開日1996-07-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Mechanistic implication of crystal structures of the cyclophilin-dipeptide complexes.
Biochemistry, 35, 1996
1FBG
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CRYSTALLOGRAPHIC STUDIES OF THE CATALYTIC MECHANISM OF THE NEUTRAL FORM OF FRUCTOSE-1,6-BISPHOSPHATASE
分子名称: 2,5-anhydro-1,6-di-O-phosphono-D-mannitol, FRUCTOSE 1,6-BISPHOSPHATASE, MANGANESE (II) ION
著者Zhang, Y, Liang, J.-Y, Huang, S, Ke, H, Lipscomb, W.N.
登録日1992-10-16
公開日1993-10-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase.
Biochemistry, 32, 1993
2OUN
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crystal structure of PDE10A2 in complex with AMP
分子名称: ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, ZINC ION, ...
著者Wang, H.C, Liu, Y.D, Hou, J, Zheng, M.Y, Robinson, H, Ke, H.M.
登録日2007-02-12
公開日2007-03-20
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献From the Cover: Structural insight into substrate specificity of phosphodiesterase 10.
Proc.Natl.Acad.Sci.Usa, 104, 2007
3B83
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Computer-Based Redesign of a beta Sandwich Protein Suggests that Extensive Negative Design Is Not Required for De Novo beta Sheet Design.
分子名称: TEN-D3
著者Hu, X, Ke, H, Kuhlman, B.
登録日2007-10-31
公開日2008-11-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Computer-Based Redesign of a beta Sandwich Protein Suggests that Extensive Negative Design Is Not Required for De Novo beta Sheet Design.
Structure, 16, 2008
3LFV
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BU of 3lfv by Molmil
crystal structure of unliganded PDE5A GAF domain
分子名称: cGMP-specific 3',5'-cyclic phosphodiesterase
著者Wang, H, Robinson, H, Ke, H.
登録日2010-01-18
公開日2010-09-22
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Conformation changes, N-terminal involvement, and cGMP signal relay in the phosphodiesterase-5 GAF domain.
J.Biol.Chem., 285, 2010
3MF0
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Crystal structure of PDE5A GAF domain (89-518)
分子名称: cGMP-specific 3',5'-cyclic phosphodiesterase
著者Wang, H, Robinson, H, Ke, H.
登録日2010-04-01
公開日2010-09-22
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Conformation changes, N-terminal involvement, and cGMP signal relay in the phosphodiesterase-5 GAF domain.
J.Biol.Chem., 285, 2010
1KKG
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NMR Structure of Ribosome-Binding Factor A (RbfA)
分子名称: ribosome-binding factor A
著者Huang, Y.J, Swapna, G.V.T, Rajan, P.K, Ke, H, Xia, B, Shukla, K, Inouye, M, Montelione, G.T, Northeast Structural Genomics Consortium (NESG)
登録日2001-12-07
公開日2003-03-18
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution NMR Structure of Ribosome-binding Factor A (RbfA), A Cold-shock Adaptation Protein from Escherichia coli
J.Mol.Biol., 327, 2003
1M63
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Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes
分子名称: CALCINEURIN B SUBUNIT ISOFORM 1, CALCIUM ION, CYCLOSPORIN A, ...
著者Huai, Q, Kim, H.-Y, Liu, Y, Zhao, Y, Mondragon, A, Liu, J.O, Ke, H.
登録日2002-07-12
公開日2002-09-25
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of Calcineurin-Cyclophilin-Cyclosporin Shows Common But Distinct Recognition of Immunophilin-Drug Complexes
Proc.Natl.Acad.Sci.USA, 99, 2002
3LNX
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Second PDZ domain from human PTP1E
分子名称: IODIDE ION, THIOCYANATE ION, Tyrosine-protein phosphatase non-receptor type 13
著者Zhang, J, Chang, A, Ke, H, Phillips Jr, G.N, Lee, A.L, Center for Eukaryotic Structural Genomics (CESG)
登録日2010-02-03
公開日2010-02-23
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.642 Å)
主引用文献Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E.
Biochemistry, 49, 2010
1OYN
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Crystal structure of PDE4D2 in complex with (R,S)-rolipram
分子名称: ROLIPRAM, ZINC ION, cAMP-specific phosphodiesterase PDE4D2
著者Huai, Q, Wang, H, Sun, Y, Kim, H.Y, Liu, Y, Ke, H.
登録日2003-04-05
公開日2003-07-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity
Structure, 11, 2003
1Q2U
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Crystal structure of DJ-1/RS and implication on familial Parkinson's disease
分子名称: RNA-binding protein regulatory subunit
著者Huai, Q, Sun, Y, Wang, H, Chin, L.S, Li, L, Robinson, H, Ke, H.
登録日2003-07-26
公開日2003-10-07
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structure of DJ-1/RS and implication on familial Parkinson's disease
Febs Lett., 549, 2003
1Q9M
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Three dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity
分子名称: ROLIPRAM, ZINC ION, cAMP-specific phosphodiesterase PDE4D2
著者Huai, Q, Wang, H, Sun, Y, Kim, H.Y, Liu, Y, Ke, H.
登録日2003-08-25
公開日2003-09-02
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Three dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity
Structure, 11, 2003
3LNY
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Second PDZ domain from human PTP1E in complex with RA-GEF2 peptide
分子名称: Rap guanine nucleotide exchange factor 6, SULFATE ION, THIOCYANATE ION, ...
著者Zhang, J, Chang, A, Ke, H, Phillips Jr, G.N, Lee, A.L, Center for Eukaryotic Structural Genomics (CESG)
登録日2010-02-03
公開日2010-03-23
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E.
Biochemistry, 49, 2010
3V94
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TcrPDEC1 catalytic domain in complex with inhibitor wyq16
分子名称: Cyclic nucleotide specific phosphodiesterase, MAGNESIUM ION, ZINC ION, ...
著者Wang, H, Kunz, S, Chen, G, Seebeck, T, Wan, Y, Robinson, H, Martinelli, S, Ke, H.
登録日2011-12-23
公開日2012-02-22
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献TcrPDEC1 catalytic domain in complex with inhibitor wyq16
To be Published
5K02
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Structure of human SOD1 with T2D mutation
分子名称: COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION
著者Fay, J.M, Zhu, C, Cui, W, Ke, H, Dokholyan, N.V.
登録日2016-05-17
公開日2016-11-23
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献A Phosphomimetic Mutation Stabilizes SOD1 and Rescues Cell Viability in the Context of an ALS-Associated Mutation.
Structure, 24, 2016
2H40
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Crystal structure of the catalytic domain of unliganded PDE5
分子名称: MAGNESIUM ION, ZINC ION, cGMP-specific 3',5'-cyclic phosphodiesterase
著者Wang, H, Liu, Y, Huai, Q, Cai, J, Zoraghi, R, Francis, S.H, Corbin, J.D, Robinson, H, Xin, Z, Lin, G, Ke, H.
登録日2006-05-23
公開日2006-06-06
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development
J.Biol.Chem., 281, 2006
2FM5
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Crystal structure of PDE4D2 in complex with inhibitor L-869299
分子名称: (R)-3-(2-(3-CYCLOPROPOXY-4-(DIFLUOROMETHOXY)PHENYL)-2-(5-(1,1,1,3,3,3-HEXAFLUORO-2-HYDROXYPROPAN-2-YL)THIAZOL-2-YL)ETHYL)PYRIDINE 1-OXIDE, MAGNESIUM ION, ZINC ION, ...
著者Huai, Q, Sun, Y, Wang, H, Macdonald, D, Aspiotis, R, Robinson, H, Huang, Z, Ke, H.
登録日2006-01-07
公開日2006-03-28
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Enantiomer Discrimination Illustrated by the High Resolution Crystal Structures of Type 4 Phosphodiesterase
J.Med.Chem., 49, 2006
2FM0
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Crystal structure of PDE4D in complex with L-869298
分子名称: (S)-3-(2-(3-CYCLOPROPOXY-4-(DIFLUOROMETHOXY)PHENYL)-2-(5-(1,1,1,3,3,3-HEXAFLUORO-2-HYDROXYPROPAN-2-YL)THIAZOL-2-YL)ETHY L)PYRIDINE 1-OXIDE, MAGNESIUM ION, ZINC ION, ...
著者Huai, Q, Sun, Y, Wang, H, Macdonald, D, Aspiotis, R, Robinson, H, Huang, Z, Ke, H.
登録日2006-01-06
公開日2006-03-28
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Enantiomer Discrimination Illustrated by the High Resolution Crystal Structures of Type 4 Phosphodiesterase
J.Med.Chem., 49, 2006
2HD1
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Crystal structure of PDE9 in complex with IBMX
分子名称: 3-ISOBUTYL-1-METHYLXANTHINE, MAGNESIUM ION, Phosphodiesterase 9A, ...
著者Huai, Q, Wang, H, Zhang, W, Colman, R.W, Robinson, H, Ke, H.
登録日2006-06-19
公開日2006-06-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor IBMX binding
Proc.Natl.Acad.Sci.USA, 101, 2004
1FPB
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CRYSTAL STRUCTURE OF THE NEUTRAL FORM OF FRUCTOSE 1,6-BISPHOSPHATASE COMPLEXED WITH REGULATORY INHIBITOR FRUCTOSE 2,6-BISPHOSPHATE AT 2.6-ANGSTROMS RESOLUTION
分子名称: 2,6-di-O-phosphono-beta-D-fructofuranose, FRUCTOSE 1,6-BISPHOSPHATASE
著者Liang, J.Y, Huang, S, Zhang, Y, Ke, H, Lipscomb, W.N.
登録日1992-02-03
公開日1993-10-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of the neutral form of fructose 1,6-bisphosphatase complexed with regulatory inhibitor fructose 2,6-bisphosphate at 2.6-A resolution.
Proc.Natl.Acad.Sci.USA, 89, 1992
3V93
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unliganded structure of TcrPDEC1 catalytic domain
分子名称: Cyclic nucleotide specific phosphodiesterase, MAGNESIUM ION, ZINC ION
著者Wang, H, Kunz, S, Chen, G, Seebeck, T, Wan, Y, Robinson, H, Martinelli, S, Ke, H.
登録日2011-12-23
公開日2012-02-22
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors.
J.Biol.Chem., 287, 2012
1PTW
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The Crystal Structure of AMP-Bound PDE4 Suggests a Mechanism for Phosphodiesterase Catalysis
分子名称: ADENOSINE MONOPHOSPHATE, ZINC ION, cAMP-specific phosphodiesterase PDE4D2
著者Huai, Q, Colicelli, J, Ke, H.
登録日2003-06-23
公開日2003-11-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The crystal structure of AMP-bound PDE4 suggests a mechanism for phosphodiesterase catalysis
Biochemistry, 42, 2003
2H42
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Crystal structure of PDE5 in complex with sildenafil
分子名称: 5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE, MAGNESIUM ION, ZINC ION, ...
著者Wang, H, Ke, H.
登録日2006-05-23
公開日2006-06-06
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development
J.Biol.Chem., 281, 2006
2H44
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Crystal structure of PDE5A1 in complex with icarisid II
分子名称: 5,7-DIHYDROXY-2-(4-METHOXYPHENYL)-8-(3-METHYLBUTYL)-4-OXO-4H-CHROMEN-3-YL 6-DEOXY-ALPHA-L-MANNOPYRANOSIDE, MAGNESIUM ION, ZINC ION, ...
著者Wang, H, Ke, H.
登録日2006-05-23
公開日2006-06-06
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development
J.Biol.Chem., 281, 2006

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