2FM0
Crystal structure of PDE4D in complex with L-869298
Summary for 2FM0
Entry DOI | 10.2210/pdb2fm0/pdb |
Related | 2FM5 |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | pde. enantiomer binding, inhibitor selectivity, camp signalling, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q08499 |
Total number of polymer chains | 4 |
Total formula weight | 168736.21 |
Authors | Huai, Q.,Sun, Y.,Wang, H.,Macdonald, D.,Aspiotis, R.,Robinson, H.,Huang, Z.,Ke, H. (deposition date: 2006-01-06, release date: 2006-03-28, Last modification date: 2024-04-03) |
Primary citation | Huai, Q.,Sun, Y.,Wang, H.,Macdonald, D.,Aspiotis, R.,Robinson, H.,Huang, Z.,Ke, H. Enantiomer Discrimination Illustrated by the High Resolution Crystal Structures of Type 4 Phosphodiesterase J.Med.Chem., 49:1867-1873, 2006 Cited by PubMed: 16539372DOI: 10.1021/jm051273d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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