2FM0
Crystal structure of PDE4D in complex with L-869298
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| C | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| C | 0007165 | biological_process | signal transduction |
| C | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| D | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| D | 0007165 | biological_process | signal transduction |
| D | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 501 |
| Chain | Residue |
| A | HIS164 |
| A | HIS200 |
| A | ASP201 |
| A | ASP318 |
| A | HOH602 |
| A | HOH607 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 502 |
| Chain | Residue |
| A | HOH605 |
| A | HOH606 |
| A | HOH607 |
| A | ASP201 |
| A | HOH603 |
| A | HOH604 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN B 503 |
| Chain | Residue |
| B | HIS164 |
| B | HIS200 |
| B | ASP201 |
| B | ASP318 |
| B | HOH603 |
| B | HOH608 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 504 |
| Chain | Residue |
| B | ASP201 |
| B | HOH604 |
| B | HOH605 |
| B | HOH606 |
| B | HOH607 |
| B | HOH608 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN C 505 |
| Chain | Residue |
| C | HIS164 |
| C | HIS200 |
| C | ASP201 |
| C | ASP318 |
| C | HOH604 |
| C | HOH609 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 506 |
| Chain | Residue |
| C | ASP201 |
| C | HOH605 |
| C | HOH606 |
| C | HOH607 |
| C | HOH608 |
| C | HOH609 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN D 507 |
| Chain | Residue |
| D | HIS164 |
| D | HIS200 |
| D | ASP201 |
| D | ASP318 |
| D | HOH605 |
| D | HOH610 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG D 508 |
| Chain | Residue |
| D | ASP201 |
| D | HOH606 |
| D | HOH607 |
| D | HOH608 |
| D | HOH609 |
| D | HOH610 |
| site_id | AC9 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE M98 A 601 |
| Chain | Residue |
| A | MET273 |
| A | ASP318 |
| A | ASN321 |
| A | PRO322 |
| A | TYR329 |
| A | TRP332 |
| A | THR333 |
| A | ILE336 |
| A | MET357 |
| A | GLN369 |
| A | PHE372 |
| A | ILE376 |
| A | HOH608 |
| A | HOH614 |
| A | HOH615 |
| site_id | BC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE M98 B 602 |
| Chain | Residue |
| B | MET273 |
| B | ASP318 |
| B | ASN321 |
| B | PRO322 |
| B | TYR329 |
| B | TRP332 |
| B | THR333 |
| B | ILE336 |
| B | MET357 |
| B | GLN369 |
| B | PHE372 |
| B | ILE376 |
| B | HOH603 |
| B | HOH609 |
| B | HOH616 |
| site_id | BC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE M98 C 603 |
| Chain | Residue |
| C | MET273 |
| C | ASP318 |
| C | ASN321 |
| C | PRO322 |
| C | TYR329 |
| C | TRP332 |
| C | THR333 |
| C | ILE336 |
| C | MET357 |
| C | GLN369 |
| C | PHE372 |
| C | ILE376 |
| C | HOH604 |
| C | HOH608 |
| C | HOH610 |
| C | HOH613 |
| C | HOH616 |
| site_id | BC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE M98 D 604 |
| Chain | Residue |
| D | PRO322 |
| D | TYR329 |
| D | TRP332 |
| D | THR333 |
| D | ILE336 |
| D | MET357 |
| D | GLN369 |
| D | PHE372 |
| D | ILE376 |
| D | HOH611 |
| D | HOH665 |
| D | THR271 |
| D | MET273 |
| D | ASP318 |
| D | ASN321 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF |
| Chain | Residue | Details |
| A | HIS200-PHE211 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q07343 |
| Chain | Residue | Details |
| A | HIS160 | |
| B | HIS160 | |
| C | HIS160 | |
| D | HIS160 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 |
| Chain | Residue | Details |
| B | ASN321 | |
| B | GLN369 | |
| C | HIS160 | |
| C | ASN321 | |
| C | GLN369 | |
| D | HIS160 | |
| D | ASN321 | |
| D | GLN369 | |
| A | HIS160 | |
| A | ASN321 | |
| A | GLN369 | |
| B | HIS160 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3 |
| Chain | Residue | Details |
| A | HIS164 | |
| B | HIS164 | |
| C | HIS164 | |
| D | HIS164 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 |
| Chain | Residue | Details |
| C | HIS200 | |
| C | ASP318 | |
| D | HIS200 | |
| D | ASP318 | |
| A | HIS200 | |
| A | ASP318 | |
| B | HIS200 | |
| B | ASP318 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW |
| Chain | Residue | Details |
| A | ASP201 | |
| A | PHE372 | |
| B | ASP201 | |
| B | PHE372 | |
| C | ASP201 | |
| C | PHE372 | |
| D | ASP201 | |
| D | PHE372 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) |
| Chain | Residue | Details |
| C | LYS85 | |
| D | LYS85 | |
| A | LYS85 | |
| B | LYS85 |
