2FM0

Crystal structure of PDE4D in complex with L-869298

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	polymer	361	41523.9	4	UniProt (Q08499) Pfam (PF00233)	Homo sapiens (human)	DPDE3, PDE43
2	E, H, K, N (A, B, C, D)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
3	F, I, L, O (A, B, C, D)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
4	G, J, M, P (A, B, C, D)	(S)-3-(2-(3-CYCLOPROPOXY-4-(DIFLUOROMETHOXY)PHENYL)-2-(5-(1,1,1,3,3,3-HEXAFLUORO-2-HYDROXYPROPAN-2-YL)THIAZOL-2-YL)ETHY L)PYRIDINE 1-OXIDE	non-polymer		570.5	4	Chemie (M98)
5	Q, R, S, T (A, B, C, D)	water	water		18.0	374	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	166095.5
Non-Polymers*	Number of molecules	12
	Total formula weight	2640.7
All*	Total formula weight	168736.2

*Water molecules are not included.