1PTW

The Crystal Structure of AMP-Bound PDE4 Suggests a Mechanism for Phosphodiesterase Catalysis

Summary for 1PTW

Entry DOI	10.2210/pdb1ptw/pdb
Descriptor	cAMP-specific phosphodiesterase PDE4D2, ZINC ION, ADENOSINE MONOPHOSPHATE, ... (4 entities in total)
Functional Keywords	catalytic mechanism, camp hydrolysis crystal structure, binuclear catalysis, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): Q08499
Total number of polymer chains	4
Total formula weight	167491.25
Authors	Huai, Q.,Colicelli, J.,Ke, H. (deposition date: 2003-06-23, release date: 2003-11-11, Last modification date: 2024-02-14)
Primary citation	Huai, Q.,Colicelli, J.,Ke, H. The crystal structure of AMP-bound PDE4 suggests a mechanism for phosphodiesterase catalysis Biochemistry, 42:13220-13226, 2003 Cited by PubMed: 14609333 DOI: 10.1021/bi034653e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation