6QL4
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![BU of 6ql4 by Molmil](/molmil-images/mine/6ql4) | Crystal structure of nucleotide-free Mgm1 | 分子名称: | 1,2-ETHANEDIOL, Putative mitochondrial dynamin protein | 著者 | Faelber, K, Dietrich, L, Noel, J.K, Wollweber, F, Pfitzner, A.-K, Muehleip, A, Sanchez, R, Kudryashev, M, Chiaruttin, N, Lilie, H, Schlegel, J, Rosenbaum, E, Hessenberger, M, Matthaeus, C, Noe, F, Roux, A, vanderLaan, M, Kuehlbrandt, W, Daumke, O. | 登録日 | 2019-01-31 | 公開日 | 2019-07-03 | 最終更新日 | 2019-07-31 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1. Nature, 571, 2019
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6PST
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![BU of 6pst by Molmil](/molmil-images/mine/6pst) | Escherichia coli RNA polymerase promoter unwinding intermediate (TRPi1.5b) with TraR and mutant rpsT P2 promoter | 分子名称: | CHAPSO, DNA (85-MER), DNA-directed RNA polymerase subunit alpha, ... | 著者 | Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A. | 登録日 | 2019-07-13 | 公開日 | 2020-03-25 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Stepwise Promoter Melting by Bacterial RNA Polymerase. Mol.Cell, 78, 2020
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4Y4R
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![BU of 4y4r by Molmil](/molmil-images/mine/4y4r) | Crystal structure of ribosomal oxygenase NO66 dimer mutant | 分子名称: | ACETATE ION, Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66, NICKEL (II) ION | 著者 | Wang, C, Hang, T, Zang, J. | 登録日 | 2015-02-11 | 公開日 | 2015-10-07 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8. Acta Crystallogr.,Sect.D, 71, 2015
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4Y52
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![BU of 4y52 by Molmil](/molmil-images/mine/4y52) | Crystal structure of 5-Carboxycytosine Recognition by RNA Polymerase II during Transcription Elongation. | 分子名称: | DNA (29-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | 著者 | Wang, L, Chong, J, Wang, D. | 登録日 | 2015-02-11 | 公開日 | 2015-07-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex. Nature, 523, 2015
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6PT3
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![BU of 6pt3 by Molmil](/molmil-images/mine/6pt3) | Crystal structure of the active delta opioid receptor in complex with the small molecule agonist DPI-287 | 分子名称: | 4-[(R)-[(2S,5R)-4-benzyl-2,5-dimethylpiperazin-1-yl](3-hydroxyphenyl)methyl]-N,N-diethylbenzamide, Delta opioid receptor | 著者 | Claff, T, Yu, J, Blais, V, Patel, N, Martin, C, Wu, L, Han, G.W, Holleran, B.J, Van der Poorten, O, Hanson, M.A, Sarret, P, Gendron, L, Cherezov, V, Katritch, V, Ballet, S, Liu, Z, Muller, C.E, Stevens, R.C. | 登録日 | 2019-07-14 | 公開日 | 2019-12-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Elucidating the active delta-opioid receptor crystal structure with peptide and small-molecule agonists. Sci Adv, 5, 2019
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6PUU
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![BU of 6puu by Molmil](/molmil-images/mine/6puu) | Human TRPM2 bound to 8-Br-cADPR and calcium | 分子名称: | (2R,3R,4S,5R,13R,14S,15R,16R)-24-amino-18-bromo-3,4,14,15-tetrahydroxy-7,9,11,25,26-pentaoxa-17,19,22-triaza-1-azonia-8 ,10-diphosphapentacyclo[18.3.1.1^2,5^.1^13,16^.0^17,21^]hexacosa-1(24),18,20,22-tetraene-8,10-diolate 8,10-dioxide, CALCIUM ION, Transient receptor potential cation channel subfamily M member 2 | 著者 | Du, J, Lu, W, Huang, Y. | 登録日 | 2019-07-18 | 公開日 | 2019-09-25 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel. Elife, 8, 2019
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6PWC
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![BU of 6pwc by Molmil](/molmil-images/mine/6pwc) | A complex structure of arrestin-2 bound to neurotensin receptor 1 | 分子名称: | Beta-arrestin-1, Fab30 heavy chain, Fab30 light chain, ... | 著者 | Yin, W, Li, Z, Jin, M, Yin, Y.-L, de Waal, P.W, Pal, K, Gao, X, He, Y, Gao, J, Wang, X, Zhang, Y, Zhou, H, Melcher, K, Jiang, Y, Cong, Y, Zhou, X.E, Yu, X, Xu, H.E. | 登録日 | 2019-07-22 | 公開日 | 2019-12-04 | 最終更新日 | 2020-01-08 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | A complex structure of arrestin-2 bound to a G protein-coupled receptor. Cell Res., 29, 2019
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6PWX
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![BU of 6pwx by Molmil](/molmil-images/mine/6pwx) | Cryo-EM structure of RbBP5 bound to the nucleosome | 分子名称: | DNA (146-MER), Histone H2A type 1, Histone H2B 1.1, ... | 著者 | Park, S.H, Ayoub, A, Lee, Y.T, Xu, J, Zhang, W, Zhang, B, Zhang, Y, Cianfrocco, M.A, Su, M, Dou, Y, Cho, U. | 登録日 | 2019-07-23 | 公開日 | 2019-12-18 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Cryo-EM structure of the human MLL1 core complex bound to the nucleosome. Nat Commun, 10, 2019
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6PZ8
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![BU of 6pz8 by Molmil](/molmil-images/mine/6pz8) | MERS S0 trimer in complex with variable domain of antibody G2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, G2 heavy chain, ... | 著者 | Bowman, C.A, Pallesen, J, Ward, A.B. | 登録日 | 2019-07-31 | 公開日 | 2019-10-09 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.19 Å) | 主引用文献 | Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD. Cell Rep, 28, 2019
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7XNE
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![BU of 7xne by Molmil](/molmil-images/mine/7xne) | Crystal structure of CBP bromodomain liganded with Y08284 | 分子名称: | CREB-binding protein, GLYCEROL, N-[3-(1-cyclopropylpyrazol-4-yl)-2-fluoranyl-5-[(1S)-1-oxidanylethyl]phenyl]-3-ethanoyl-7-methoxy-indolizine-1-carboxamide | 著者 | Xiang, Q, Wang, C, Wu, T, Zhang, C, Hu, Q, Luo, G, Hu, J, Zhuang, X, Zou, L, Shen, H, Wu, X, Zhang, Y, Kong, X, Xu, Y. | 登録日 | 2022-04-28 | 公開日 | 2022-07-06 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer. J.Med.Chem., 65, 2022
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6BPU
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![BU of 6bpu by Molmil](/molmil-images/mine/6bpu) | Crystal structure of ferrous form of the F2-Tyr157 human cysteine dioxygenase with both uncrosslinked and crosslinked cofactor | 分子名称: | Cysteine dioxygenase type 1, FE (II) ION, GLYCEROL, ... | 著者 | Liu, A, Li, J, Shin, I. | 登録日 | 2017-11-26 | 公開日 | 2018-07-04 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Cleavage of a carbon-fluorine bond by an engineered cysteine dioxygenase. Nat. Chem. Biol., 14, 2018
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4Y93
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![BU of 4y93 by Molmil](/molmil-images/mine/4y93) | Crystal structure of the PH-TH-kinase construct of Bruton's tyrosine kinase (Btk) | 分子名称: | 4-tert-butyl-N-[2-methyl-3-(4-methyl-6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-5-oxo-4,5-dihydropyrazin-2-yl)phenyl]benzamide, CALCIUM ION, Non-specific protein-tyrosine kinase,Non-specific protein-tyrosine kinase, ... | 著者 | Wang, Q, Kuriyan, J. | 登録日 | 2015-02-16 | 公開日 | 2015-03-18 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.695 Å) | 主引用文献 | Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate. Elife, 4, 2015
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6C1U
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![BU of 6c1u by Molmil](/molmil-images/mine/6c1u) | MBD2 in complex with a deoxy-oligonucleotide | 分子名称: | 12-mer DNA, Methyl-CpG-binding domain protein 2, UNKNOWN ATOM OR ION | 著者 | Lei, M, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2018-01-05 | 公開日 | 2018-02-14 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA. J. Biol. Chem., 293, 2018
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2PLA
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![BU of 2pla by Molmil](/molmil-images/mine/2pla) | Crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein | 分子名称: | CHLORIDE ION, Glycerol-3-phosphate dehydrogenase 1-like protein, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Uppenberg, J, Smee, C, Hozjan, V, Kavanagh, K, Bunkoczi, G, Papagrigoriou, E, Pike, A.C.W, Ugochukwu, E, Umeano, C, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC) | 登録日 | 2007-04-19 | 公開日 | 2007-05-01 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein. To be Published
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4YIK
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![BU of 4yik by Molmil](/molmil-images/mine/4yik) | Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PVU | 分子名称: | 1-{2-deoxy-3,5-O-[phenyl(phosphono)methylidene]-beta-D-threo-pentofuranosyl}-5-[(E)-2-phosphonoethenyl]pyrimidine-2,4(1H,3H)-dione, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5'(3')-deoxyribonucleotidase, ... | 著者 | Pachl, P, Rezacova, P, Brynda, J. | 登録日 | 2015-03-02 | 公開日 | 2015-09-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.483 Å) | 主引用文献 | Structure-based design of a bisphosphonate 5'(3')-deoxyribonucleotidase inhibitor Medchemcomm, 6, 2015
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6Q4W
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![BU of 6q4w by Molmil](/molmil-images/mine/6q4w) | Structure of MPT-1, a GDP-Man-dependent mannosyltransferase from Leishmania mexicana | 分子名称: | LmxM MPT-1 | 著者 | Sobala, L.F, Males, A, Bastidas, L.M, Ward, T, Sernee, M.F, Ralton, J.E, Nero, T.L, Cobbold, S, Kloehn, J, Viera-Lara, M, Stanton, L, Hanssen, E, Parker, M.W, Williams, S.J, McConville, M.J, Davies, G.J. | 登録日 | 2018-12-06 | 公開日 | 2019-09-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites. Cell Host Microbe, 26, 2019
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7VCF
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![BU of 7vcf by Molmil](/molmil-images/mine/7vcf) | Cryo-EM structure of Chlamydomonas TOC-TIC supercomplex | 分子名称: | 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | 著者 | Wu, J, Yan, Z, Jin, Z, Zhang, Y. | 登録日 | 2021-09-02 | 公開日 | 2022-11-30 | 最終更新日 | 2022-12-21 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Structure of a TOC-TIC supercomplex spanning two chloroplast envelope membranes. Cell, 185, 2022
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6CEU
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![BU of 6ceu by Molmil](/molmil-images/mine/6ceu) | MBD3 MBD in complex with methylated, non-palindromic CpG DNA: alternative interpretation of crystallographic data | 分子名称: | DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*CP*TP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*AP*GP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), Methyl-CpG-binding domain protein 3, ... | 著者 | Liu, K, Tempel, W, Wernimont, A.K, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2018-02-12 | 公開日 | 2018-05-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.005 Å) | 主引用文献 | Structural analyses reveal that MBD3 is a methylated CG binder. Febs J., 286, 2019
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6CF8
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4YUN
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![BU of 4yun by Molmil](/molmil-images/mine/4yun) | Multiconformer synchrotron model of CypA at 310 K | 分子名称: | Peptidyl-prolyl cis-trans isomerase A | 著者 | Keedy, D.A, Kenner, L.R, Warkentin, M, Woldeyes, R.A, Thompson, M.C, Brewster, A.S, Van Benschoten, A.H, Baxter, E.L, Hopkins, J.B, Uervirojnangkoorn, M, McPhillips, S.E, Song, J, Mori, R.A, Holton, J.M, Weis, W.I, Brunger, A.T, Soltis, M, Lemke, H, Gonzalez, A, Sauter, N.K, Cohen, A.E, van den Bedem, H, Thorne, R.E, Fraser, J.S. | 登録日 | 2015-03-18 | 公開日 | 2015-10-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography. Elife, 4, 2015
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4YCW
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![BU of 4ycw by Molmil](/molmil-images/mine/4ycw) | Crystal structure of cladosporin in complex with plasmodium like human lysyl-tRNA synthetase mutant | 分子名称: | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, LYSINE, Lysine--tRNA ligase, ... | 著者 | Fang, P, Wang, J, Guo, M. | 登録日 | 2015-02-20 | 公開日 | 2015-06-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural Basis for Specific Inhibition of tRNA Synthetase by ATP Competitive Inhibitor Chem.Biol., 22, 2015
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6QIG
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![BU of 6qig by Molmil](/molmil-images/mine/6qig) | Metalloproteinase | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kim, H.J, Emsley, J. | 登録日 | 2019-01-18 | 公開日 | 2019-09-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure and substrate-induced activation of ADAMTS13. Nat Commun, 10, 2019
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6Q8Y
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![BU of 6q8y by Molmil](/molmil-images/mine/6q8y) | Cryo-EM structure of the mRNA translating and degrading yeast 80S ribosome-Xrn1 nuclease complex | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | 著者 | Tesina, P, Heckel, E, Cheng, J, Buschauer, R, Kater, L, Berninghausen, O, Becker, T, Beckmann, R. | 登録日 | 2018-12-16 | 公開日 | 2019-03-13 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of the 80S ribosome-Xrn1 nuclease complex. Nat.Struct.Mol.Biol., 26, 2019
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6PT0
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![BU of 6pt0 by Molmil](/molmil-images/mine/6pt0) | Cryo-EM structure of human cannabinoid receptor 2-Gi protein in complex with agonist WIN 55,212-2 | 分子名称: | CHOLESTEROL, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Xu, T.H, Xing, C, Zhuang, Y, Feng, Z, Zhou, X.E, Chen, M, Wang, L, Meng, X, Xue, Y, Wang, J, Liu, H, McGuire, T, Zhao, G, Melcher, K, Zhang, C, Xu, H.E, Xie, X.Q. | 登録日 | 2019-07-14 | 公開日 | 2020-02-12 | 最終更新日 | 2020-03-04 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM Structure of the Human Cannabinoid Receptor CB2-GiSignaling Complex. Cell, 180, 2020
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4Y6K
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![BU of 4y6k by Molmil](/molmil-images/mine/4y6k) | Complex structure of presenilin homologue PSH bound to an inhibitor | 分子名称: | N-{(2R,4S,5S)-2-benzyl-5-[(tert-butoxycarbonyl)amino]-4-hydroxy-6-phenylhexanoyl}-L-leucyl-L-phenylalaninamide, Uncharacterized protein PSH | 著者 | Dang, S, Wu, S, Wang, J, Shi, Y. | 登録日 | 2015-02-13 | 公開日 | 2015-03-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.855 Å) | 主引用文献 | Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH Proc.Natl.Acad.Sci.USA, 112, 2015
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