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PDB: 128 results
4XSK
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BU of 4xsk by Molmil
Structure of PAItrap, an uPA mutant
Descriptor: GLYCEROL, SULFATE ION, TRIETHYLENE GLYCOL, ...
Authors:Gong, L, Proulle, V, Hong, Z, Lin, Z, Liu, M, Yuan, C, Lin, L, Furie, B, Flaumenhaft, R, Andreasen, P, Furie, B, Huang, M.
Deposit date:2015-01-22
Release date:2016-02-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of PAItrap, an uPA mutant
To Be Published
4MD6
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BU of 4md6 by Molmil
Crystal structure of PDE5 in complex with inhibitor 5R
Descriptor: 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one, MAGNESIUM ION, SULFATE ION, ...
Authors:Cui, W, Huang, M, Shao, Y, Luo, H.
Deposit date:2013-08-22
Release date:2014-07-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one as a phosphodiesterase-5 inhibitor and its complex crystal structure.
Biochem Pharmacol, 89, 2014
5LHR
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BU of 5lhr by Molmil
The catalytic domain of murine urokinase-type plasminogen activator in complex with the active site binding inhibitory nanobody Nb22
Descriptor: Camelid-Derived Antibody Fragment Nb22, Urokinase-type plasminogen activator
Authors:Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHP
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BU of 5lhp by Molmil
The p-aminobenzamidine active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
Descriptor: 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment, P-AMINO BENZAMIDINE, ...
Authors:Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHN
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BU of 5lhn by Molmil
The catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
Descriptor: 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment Nb7, SULFATE ION, ...
Authors:Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P, Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHQ
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BU of 5lhq by Molmil
The EGR-cmk active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
Descriptor: 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment Nb7, L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, ...
Authors:Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHS
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BU of 5lhs by Molmil
The ligand free catalytic domain of murine urokinase-type plasminogen activator
Descriptor: NICKEL (II) ION, SULFATE ION, Urokinase-type plasminogen activator
Authors:Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.047 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5H64
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BU of 5h64 by Molmil
Cryo-EM structure of mTORC1
Descriptor: Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8
Authors:Yang, H, Wang, J, Liu, M, Chen, X, Huang, M, Tan, D, Dong, M, Wong, C.C.L, Wang, J, Xu, Y, Wang, H.
Deposit date:2016-11-10
Release date:2017-01-25
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:4.4 angstrom Resolution Cryo-EM structure of human mTOR Complex 1
Protein Cell, 7, 2016
4ZKR
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BU of 4zkr by Molmil
The crystal structure of upain-1-W3A in complex with uPA at pH9.0
Descriptor: HEXAETHYLENE GLYCOL, SULFATE ION, Urokinase-type plasminogen activator, ...
Authors:Jiang, L, Andreasen, P.A, Huang, M.
Deposit date:2015-04-30
Release date:2016-05-18
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:The crystal structure of mupain-1-IG in complex with murinised human uPA at pH7.4
To Be Published
4ZKS
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BU of 4zks by Molmil
The crystal structure of upain-1-W3A in complex with inactive uPA (uPA-S195A) at pH7.4
Descriptor: Urokinase-type plasminogen activator, upain-1-W3A
Authors:Jiang, L, Andreasen, P.A, Huang, M.
Deposit date:2015-04-30
Release date:2016-05-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The crystal structure of mupain-1-IG in complex with murinised human uPA at pH7.4
To Be Published
4ZKN
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BU of 4zkn by Molmil
The crystal structure of upain-1-W3A in complex with uPA at pH5.5
Descriptor: SULFATE ION, TETRAETHYLENE GLYCOL, Urokinase-type plasminogen activator, ...
Authors:Jiang, L, Andreasen, P.A, Huang, M.
Deposit date:2015-04-30
Release date:2016-05-18
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:The crystal structure of mupain-1-IG in complex with murinised human uPA at pH7.4
To Be Published
4ZHL
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BU of 4zhl by Molmil
The crystal structure of mupain-1-IG in complex with murinised human uPA at pH7.4
Descriptor: Urokinase-type plasminogen activator, mupain-1-IG
Authors:Jiang, L, Andreasen, P.A, Huang, M.
Deposit date:2015-04-25
Release date:2015-09-16
Last modified:2015-10-14
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Selection of High-Affinity Peptidic Serine Protease Inhibitors with Increased Binding Entropy from a Back-Flip Library of Peptide-Protease Fusions.
J.Mol.Biol., 427, 2015
4ZHM
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BU of 4zhm by Molmil
The crystal structure of mupain-1--16-IG in complex with murinised human uPA at pH7.4
Descriptor: Urokinase-type plasminogen activator, mupain-1-16-IG, piperidine-1-carboximidamide
Authors:Jiang, L, Andreasen, P.A, Huang, M.
Deposit date:2015-04-25
Release date:2015-09-16
Last modified:2015-10-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Selection of High-Affinity Peptidic Serine Protease Inhibitors with Increased Binding Entropy from a Back-Flip Library of Peptide-Protease Fusions.
J.Mol.Biol., 427, 2015
4ZKO
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BU of 4zko by Molmil
The crystal structure of upain-1-W3A in complex with uPA at pH7.4
Descriptor: C-terminal fragment of upain-1-W3A, HEXAETHYLENE GLYCOL, N-terminal fragment of upain-1-W3A, ...
Authors:Jiang, L, Andreasen, P.A, Huang, M.
Deposit date:2015-04-30
Release date:2016-05-18
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:The crystal structure of mupain-1-IG in complex with murinised human uPA at pH7.4
To Be Published
4QTH
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BU of 4qth by Molmil
Crystal structure of anti-uPAR Fab 8B12
Descriptor: anti-uPAR antibody, heavy chain, light chain
Authors:Zhao, B, Yuan, C, Luo, Z, Huang, M.
Deposit date:2014-07-08
Release date:2015-02-25
Last modified:2022-08-24
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Stabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation.
J.Mol.Biol., 427, 2015
4QTI
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BU of 4qti by Molmil
Crystal structure of human uPAR in complex with anti-uPAR Fab 8B12
Descriptor: Urokinase plasminogen activator surface receptor, anti-uPAR antibody, heavy chain, ...
Authors:Zhao, B, Yuan, C, Luo, Z, Huang, M.
Deposit date:2014-07-08
Release date:2015-02-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Stabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation.
J.Mol.Biol., 427, 2015
5GVT
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BU of 5gvt by Molmil
Crystal structures of the serine protease domain of murine plasma kallikrein
Descriptor: Plasma kallikrein, alpha-D-mannopyranose, beta-D-mannopyranose
Authors:Xu, M, Jiang, L, Huang, M.
Deposit date:2016-09-06
Release date:2017-11-22
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Crystal Structures of the Serine Protease Domain of Murine Plasma Kallikrein
Chin.J.Struct.Chem., 36, 2017
5F8T
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BU of 5f8t by Molmil
The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-2
Descriptor: CYS-PRO-LYS-ARG-PHE-M70-ALA-LEU-PHE-CYS, Plasma kallikrein light chain, SULFATE ION, ...
Authors:Xu, M, Jiang, L, Xu, P, Luo, Z, Andreasen, P, Huang, M.
Deposit date:2015-12-09
Release date:2016-12-14
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-2
To Be Published
5H7V
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BU of 5h7v by Molmil
Structure of full-length extracellular domain of HAI-1 at pH 4.6
Descriptor: Kunitz-type protease inhibitor 1
Authors:Liu, M, Huang, M.
Deposit date:2016-11-21
Release date:2017-03-29
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.82 Å)
Cite:The crystal structure of a multidomain protease inhibitor (HAI-1) reveals the mechanism of its auto-inhibition
J. Biol. Chem., 292, 2017
4IKM
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BU of 4ikm by Molmil
X-ray structure of CARD8 CARD domain
Descriptor: 1,2-ETHANEDIOL, IODIDE ION, Maltose-binding periplasmic protein, ...
Authors:Jin, T, Huang, M, Smith, P, Jiang, J, Xiao, T.
Deposit date:2012-12-26
Release date:2013-05-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4606 Å)
Cite:The structure of the CARD8 caspase-recruitment domain suggests its association with the FIIND domain and procaspases through adjacent surfaces.
Acta Crystallogr.,Sect.F, 69, 2013
6AEX
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BU of 6aex by Molmil
Crystal structure of unoccupied murine uPAR
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor
Authors:Min, L, Huang, M.
Deposit date:2018-08-06
Release date:2019-07-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.393 Å)
Cite:Crystal structure of the unoccupied murine urokinase-type plasminogen activator receptor (uPAR) reveals a tightly packed DII-DIII unit.
Febs Lett., 593, 2019
2FAT
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BU of 2fat by Molmil
An anti-urokinase plasminogen activator receptor (UPAR) antibody: Crystal structure and binding epitope
Descriptor: FAB ATN-615, heavy chain, light chain
Authors:Li, Y, Parry, G, Shi, X, Chen, L, Callahan, J.A, Mazar, A.P, Huang, M.
Deposit date:2005-12-07
Release date:2006-11-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:An anti-urokinase plasminogen activator receptor (uPAR) antibody: crystal structure and binding epitope
J.Mol.Biol., 365, 2007
5E4K
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BU of 5e4k by Molmil
Structure of ligand binding region of uPARAP at pH 7.4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, C-type mannose receptor 2, ...
Authors:Yuan, C, Huang, M.
Deposit date:2015-10-06
Release date:2016-08-10
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding
Biochem.J., 473, 2016
6A8O
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BU of 6a8o by Molmil
Crystal structures of the serine protease domain of murine plasma kallikrein with peptide inhibitor mupain-1-16
Descriptor: Plasma kallikrein, alpha-D-mannopyranose, peptide inhibitor,, ...
Authors:Xu, M, Jiang, L, Huang, M.
Deposit date:2018-07-09
Release date:2019-07-10
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217.
Febs Lett., 592, 2018
5EW6
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BU of 5ew6 by Molmil
Structure of ligand binding region of uPARAP at pH 7.4 without calcium
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C-type mannose receptor 2, ...
Authors:Yuan, C, Huang, M.
Deposit date:2015-11-20
Release date:2016-08-10
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding
Biochem.J., 473, 2016

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