6AEX

Crystal structure of unoccupied murine uPAR

6AEX の概要

• エントリーDOI: 10.2210/pdb6aex/pdb
• 分子名称: Urokinase plasminogen activator surface receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: upar, tfpds, cell invasion
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30391.98

構造登録者

Min, L.,Huang, M. (登録日: 2018-08-06, 公開日: 2019-07-17, 最終更新日: 2024-10-16)

主引用文献

Liu, M.,Lin, L.,Hoyer-Hansen, G.,Ploug, M.,Li, H.,Jiang, L.,Yuan, C.,Li, J.,Huang, M.
Crystal structure of the unoccupied murine urokinase-type plasminogen activator receptor (uPAR) reveals a tightly packed DII-DIII unit.
Febs Lett., 593:1236-1247, 2019

PubMed Abstract: The urokinase-type plasminogen activator receptor (uPAR) is a cell surface receptor that is capable of binding to a range of extracellular proteins and triggering a series of proteolytic and signaling events. Previous structural studies of uPAR with its ligands uPA and vitronectin revealed that its three domains (DI, DII, and DIII) form a large hydrophobic cavity to accommodate uPA. In the present study, the structure of unoccupied murine uPAR (muPAR) is determined. The structure of DII and DIII of muPAR is well defined and forms a compact globular unit, while DI could not be traced. Molecular dynamic simulations further confirm the rigid binding interface between DII and DIII. This study shows overall structural flexibility of uPAR in the absence of uPA.

PubMed: 31044429
DOI: 10.1002/1873-3468.13397
主引用文献が同じPDBエントリー

実験手法

X-RAY DIFFRACTION (2.393 Å)