4ZHM
The crystal structure of mupain-1--16-IG in complex with murinised human uPA at pH7.4
Summary for 4ZHM
Entry DOI | 10.2210/pdb4zhm/pdb |
Descriptor | mupain-1-16-IG, Urokinase-type plasminogen activator, piperidine-1-carboximidamide, ... (4 entities in total) |
Functional Keywords | peptides inhibitor, upa, serine protease, hydrolase inhibitor-hydrolase complex, hydrolase inhibitor/hydrolase |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P00749 |
Total number of polymer chains | 2 |
Total formula weight | 29044.14 |
Authors | Jiang, L.,Andreasen, P.A.,Huang, M. (deposition date: 2015-04-25, release date: 2015-09-16, Last modification date: 2015-10-14) |
Primary citation | Srensen, H.P.,Xu, P.,Jiang, L.,Kromann-Hansen, T.,Jensen, K.J.,Huang, M.,Andreasen, P.A. Selection of High-Affinity Peptidic Serine Protease Inhibitors with Increased Binding Entropy from a Back-Flip Library of Peptide-Protease Fusions. J.Mol.Biol., 427:3110-3122, 2015 Cited by PubMed: 26281711DOI: 10.1016/j.jmb.2015.08.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report