4ZHM
The crystal structure of mupain-1--16-IG in complex with murinised human uPA at pH7.4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (P) | mupain-1-16-IG | polymer | 10 | 1047.2 | 1 | synthetic construct | ||
| 2 | B (U) | Urokinase-type plasminogen activator | polymer | 247 | 27869.7 | 1 | UniProt (P00749) Pfam (PF00089) | Homo sapiens (Human) | uPA |
| 3 | C (P) | piperidine-1-carboximidamide | non-polymer | 127.2 | 1 | Chemie (MRZ) | |||
| 4 | D, E (P, U) | water | water | 18.0 | 57 | Chemie (HOH) |
Sequence modifications
U: 16 - 244 (UniProt: P00749)
| PDB | External Database | Details |
|---|---|---|
| Tyr 99 | His 272 | engineered mutation |
| Ala 122 | Cys 299 | engineered mutation |
| Gln 145 | Asn 322 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28916.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 127.2 | |
| All* | Total formula weight | 29044.1 |
