4ZHM
The crystal structure of mupain-1--16-IG in complex with murinised human uPA at pH7.4
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | P | mupain-1-16-IG | polymer | 10 | 1047.2 | 1 | synthetic construct | ||
2 | U | Urokinase-type plasminogen activator | polymer | 247 | 27869.7 | 1 | UniProt (P00749) Pfam (PF00089) In PDB | Homo sapiens (Human) | uPA |
3 | P | piperidine-1-carboximidamide | non-polymer | 127.2 | 1 | Chemie (MRZ) | |||
4 | water | water | 18.0 | 57 | Chemie (HOH) |
Sequence modifications
U: 16 - 244 (UniProt: P00749)
PDB | External Database | Details |
---|---|---|
Tyr 99 | His 272 | engineered mutation |
Ala 122 | Cys 299 | engineered mutation |
Gln 145 | Asn 322 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 28916.9 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 127.2 | |
All* | Total formula weight | 29044.1 |